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Review
. 2022 May 24;14(11):2131.
doi: 10.3390/polym14112131.

Surveying the Oral Drug Delivery Avenues of Novel Chitosan Derivatives

Iyyakkannu Sivanesan  1 , Shadma Tasneem  2 , Nazim Hasan  2 , Juhyun Shin  3 , Manikandan Muthu  4 , Judy Gopal  4 , Jae-Wook Oh  3
Affiliations
Review

Surveying the Oral Drug Delivery Avenues of Novel Chitosan Derivatives

Iyyakkannu Sivanesan et al. Polymers (Basel). .

Abstract

Chitosan has come a long way in biomedical applications: drug delivery is one of its core areas of imminent application. Chitosan derivatives are the new generation variants of chitosan. These modified chitosans have overcome limitations and progressed in the area of drug delivery. This review briefly surveys the current chitosan derivatives available for biomedical applications. The biomedical applications of chitosan derivatives are revisited and their key inputs for oral drug delivery have been discussed. The limited use of the vast chitosan resources for oral drug delivery applications, speculated to be probably due to the interdisciplinary nature of this research, is pointed out in the discussion. Chitosan-derivative synthesis and practical implementation for oral drug delivery require distinct expertise from chemists and pharmacists. The lack of enthusiasm could be related to the inadequacy in the smooth transfer of the synthesized derivatives to the actual implementers. With thiolated chitosan derivatives predominating the oral delivery of drugs, the need for representation from the vast array of ready-to-use chitosan derivatives is emphasized. There is plenty to explore in this direction.

Keywords: biomedical applications; chitosan; chitosan derivative; drug delivery; oral delivery.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Overview of various chemical modification processes that go into the making of chitosan derivatives.
Figure 2
Figure 2
Mechanisms of drug release in chitosan and its derivatives.
Figure 3
Figure 3
Listings of the limitations in oral drug delivery that chitosan and its derivatives have helped overcome.
Figure 4
Figure 4
Comparative bar diagrams of research articles published in the area of (a) chitosans and drug delivery (b) chitosan derivatives and drug delivery (c) chitosan derivatives for oral drug delivery, based on our pubmed search.
See this image and copyright information in PMC

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