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Review
. 2022 May 26;27(11):3450.
doi: 10.3390/molecules27113450.

Phytochemistry, Bioactivities and Traditional Uses of Michelia × alba

Kian-Kai Cheng  1   2 , Muhammad Helmi Nadri  1   2 , Nor Zalina Othman  1   2 , Siti Nor Azlina Abd Rashid  1   2 , Ying-Chin Lim  3 , Hong-Yeng Leong  1   2
Affiliations
Review

Phytochemistry, Bioactivities and Traditional Uses of Michelia × alba

Kian-Kai Cheng et al. Molecules. .

Abstract

Michelia × alba (M. alba) is a flowering tree best known for its essential oil, which has long been used as a fragrance ingredient for perfume and cosmetics. In addition, the plant has been used in traditional medicine in Asia and dates back hundreds of years. To date, there is a limited number of publications on the bioactivities of M. alba, which focused on its tyrosinase inhibition, antimicrobial, antidiabetic, anti-inflammatory, and antioxidant activities. Nevertheless, M. alba may have additional unexplored bioactivities associated with its bioactive compounds such as linalool (72.8% in flower oil and 80.1% in leaf oil), α-terpineol (6.04% flower oil), phenylethyl alcohol (2.58% flower oil), β-pinene (2.39% flower oil), and geraniol (1.23% flower oil). Notably, these compounds have previously been reported to exhibit therapeutic activities such as anti-cancer, anti-inflammation, anti-depression, anti-ulcer, anti-hypertriglyceridemia, and anti-hypertensive activities. In this review paper, we examine and discuss the scientific evidence on the phytochemistry, bioactivities, and traditional uses of M. alba. Here, we report a total of 168 M. alba biological compounds and highlight the therapeutic potential of its key bioactive compounds. This review may provide insights into the therapeutic potential of M. alba and its biologically active components for the prevention and treatment of diseases and management of human health and wellness.

Keywords: Magnolia alba; bioactive compounds; therapeutic.

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Conflict of interest statement

The authors declare that there is no conflict of interest regarding the publication of this paper.

Figures

Figure 1
Figure 1
Photos of M. alba. (a) carpels, (b) flower, (c) leaves, and (d) M. alba plant (photo taken on M. alba planted in Universiti Teknologi Malaysia Pagoh Campus).
Figure 2
Figure 2
The main aroma constituents in the essential oil of flower, stem, and leaves of M. alba. (a) Linalool, (b) caryophyllene, (c) β-cubebene, (d) eucalyptol, (e) eugenol methyl ether, (f) α-fenchene, (g) germacrene D, (h) α-humulene, (i) (E)-ocimene, (j) nerolidol, (k) 2,4-diisopropenyl-1-methyl-1-vinylcyclohexane, (l) isoeugenyl methyl ether [11,14,15,16].
Figure 3
Figure 3
A summary of bioactivities of selected bioactive compounds in M. alba.
See this image and copyright information in PMC

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