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Review
. 2022 Jan 31:2022:4974410.
doi: 10.1155/2022/4974410. eCollection 2022.

Sarcopenia and Mortality Risk of Patients with Sepsis: A Meta-Analysis

Wei Liu  1   2   3 , Chenghuan Hu  1   2   3 , Shuangping Zhao  1   2   3
Affiliations
Review

Sarcopenia and Mortality Risk of Patients with Sepsis: A Meta-Analysis

Wei Liu et al. Int J Clin Pract. .

Abstract

Background: The association between sarcopenia at admission and mortality in patients with sepsis has not been comprehensively evaluated. We performed a meta-analysis to systematically evaluate the above association.

Methods: This meta-analysis included relevant observational studies from Medline, Embase, and Web of Science databases. A random-effect model after incorporation of the intrastudy heterogeneity was selected to pool the results. Subgroup analyses were applied to evaluate the influences of study characteristics on relationship.

Results: Ten cohort studies including 2396 patients with sepsis were included, and 1496 (62.4%) of them had sarcopenia at presentation. Pooled results showed that compared to those without sarcopenia, septic patients with sarcopenia had a significantly increased early (in-hospital or 1-month) mortality risk (risk ration (RR): 2.14, 95% confidence interval (CI): 1.60-2.87, P < 0.001; I 2 = 46%). Subgroup analyses showed consistent association between sarcopenia and increased acute mortality risk in septic patients which were not affected by study characteristics such as study design, country of the study, clinical settings, diagnostic criteria for sepsis, age, gender of the patients, and methods for diagnosis of sarcopenia (P for all subgroup analyses >0.05). Further meta-analyses showed that sarcopenia was also associated with increased mortality risk in septic patients at 3-6 months (RR: 2.13, 95% CI: 1.58-2.89, P < 0.001; I 2 = 0%) and at 1 year (RR: 1.57, 95% CI: 1.09-2.24, P = 0.01; I 2 = 29%).

Conclusions: Current evidence suggests that sarcopenia may be a predictor of mortality in patients with sepsis.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Flowchart of the database search and study identification.
Figure 2
Figure 2
Forest plots for the meta-analysis of the association between sarcopenia and mortality risk in patients with sepsis. (a) Association between sarcopenia and early mortality risk. (b) Association between sarcopenia and mortality risk at 3–6 months after discharge. (c) Association between sarcopenia and mortality risk at 1 year after discharge.
Figure 3
Figure 3
Funnel plots for the publication bias underlying the meta-analysis of the association between sarcopenia and early mortality risk.
See this image and copyright information in PMC

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References

    1. Chiu C., Legrand M. Epidemiology of sepsis and septic shock. Current Opinion in Anaesthesiology . 2021;34(2):71–76. - PubMed
    1. Evans L., Rhodes A., Alhazzani W. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Medicine . 2021;47(11) doi: 10.1007/s00134-021-06506-y. - DOI - PMC - PubMed
    1. Font M. D., Thyagarajan B., Khanna A. K. Sepsis and Septic Shock - basics of diagnosis, pathophysiology and clinical decision making. Medical Clinics of North America . 2020;104(4):573–585. doi: 10.1016/j.mcna.2020.02.011. - DOI - PubMed
    1. Markwart R., Saito H., Harder T. Epidemiology and burden of sepsis acquired in hospitals and intensive care units: a systematic review and meta-analysis. Intensive Care Medicine . 2020;46(8):1536–1551. doi: 10.1007/s00134-020-06106-2. - DOI - PMC - PubMed
    1. Fleischmann-Struzek C., Mellhammar L., Rose N. Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis. Intensive Care Medicine . 2020;46(8):1552–1562. doi: 10.1007/s00134-020-06151-x. - DOI - PMC - PubMed