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Comment
. 2022 Aug 5;12(8):1834.
doi: 10.1158/2159-8290.CD-RW2022-108.

Aged Lungs Enable Metastatic Outgrowth of Dormant Melanoma Cells

No authors listed
Comment

Aged Lungs Enable Metastatic Outgrowth of Dormant Melanoma Cells

No authors listed. Cancer Discov. .

Abstract

Aged lung fibroblasts promote reactivation of dormant melanoma cells by secreting a WNT antagonist.

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  • Stromal changes in the aged lung induce an emergence from melanoma dormancy.
    Fane ME, Chhabra Y, Alicea GM, Maranto DA, Douglass SM, Webster MR, Rebecca VW, Marino GE, Almeida F, Ecker BL, Zabransky DJ, Hüser L, Beer T, Tang HY, Kossenkov A, Herlyn M, Speicher DW, Xu W, Xu X, Jaffee EM, Aguirre-Ghiso JA, Weeraratna AT. Fane ME, et al. Nature. 2022 Jun;606(7913):396-405. doi: 10.1038/s41586-022-04774-2. Epub 2022 Jun 1. Nature. 2022. PMID: 35650435 Free PMC article.

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