Three residues in the BTB domain promote a good partnership between NuRD and Thpok
- PMID: 35687694
- DOI: 10.1126/sciimmunol.abq1408
Three residues in the BTB domain promote a good partnership between NuRD and Thpok
Abstract
Among the BTB-ZF transcription factor family, three amino acids in the BTB domain make Thpok unique in repressing cytotoxic lineage-related genes via recruitment of the NuRD chormatin-remodeling complex (see the related Research Article by Gao et al.).
Comment on
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NuRD complex recruitment to Thpok mediates CD4+ T cell lineage differentiation.Sci Immunol. 2022 Jun 10;7(72):eabn5917. doi: 10.1126/sciimmunol.abn5917. Epub 2022 Jun 10. Sci Immunol. 2022. PMID: 35687698 Free PMC article.
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