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Review
. 2022 Dec;20(12):2684-2695.e3.
doi: 10.1016/j.cgh.2022.05.022. Epub 2022 Jun 7.

Progress in Gastroparesis - A Narrative Review of the Work of the Gastroparesis Clinical Research Consortium

Pankaj J Pasricha  1 , Madhusudan Grover  2 , Katherine P Yates  3 , Thomas L Abell  4 , Kenneth L Koch  5 , Richard W McCallum  6 , Irene Sarosiek  6 , Cheryl E Bernard  2 , Braden Kuo  7 , Robert Bulat  8 , Robert J Shulman  9 , Bruno P Chumpitazi  9 , James Tonascia  3 , Laura A Miriel  3 , Laura A Wilson  3 , Mark L Van Natta  3 , Emily Mitchell  3 , Frank Hamilton  10 , Gianrico Farrugia  2 , Henry P Parkman  11 ; NIDDK/NIH GpCRC consortium
Affiliations
Review

Progress in Gastroparesis - A Narrative Review of the Work of the Gastroparesis Clinical Research Consortium

Pankaj J Pasricha et al. Clin Gastroenterol Hepatol. 2022 Dec.

Abstract

The Gastroparesis Clinical Research Consortium is a multicenter coalition created and funded by the National Institutes of Diabetes and Digestive and Kidney Disorders, with a mission to advance understanding of the pathophysiology of gastroparesis and develop an effective treatment for patients with symptomatic gastroparesis. In this review, we summarize the results of the published Gastroparesis Clinical Research Consortium studies as a ready and convenient resource for gastroenterologists and others to provide a clear understanding of the consortium's experience and perspective on gastroparesis and related disorders.

Keywords: Clinical Trials; Functional Dyspepsia; Gastroparesis; Motility Disorders.

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Conflict of interest statement

Conflict of Interest. The authors declare that there are no conflict of interests in this study.

Figures

Figure 1:
Figure 1:
Summary of cellular, transcriptomic, and proteomic analysis of full thickness gastric tissue conducted by the GpCRC.
Figure 2:
Figure 2:
Summary of the relationship between gastroparesis and functional dyspepsia showing similar myenteric pathology, the lability of gastric emptying without a change in symptoms or Rome III classification.
See this image and copyright information in PMC

References

    1. Parkman HP, Yates K, Hasler WL, et al. Clinical features of idiopathic gastroparesis vary with sex, body mass, symptom onset, delay in gastric emptying, and gastroparesis severity. Gastroenterology 2011;140:101–15. - PMC - PubMed
    1. Pasricha PJ, Grover M, Yates KP, et al. Functional Dyspepsia and Gastroparesis in Tertiary Care are Interchangeable Syndromes With Common Clinical and Pathologic Features. Gastroenterology 2021;160:2006–2017. - PMC - PubMed
    1. Parkman HP, Sharkey E, McCallum RW, et al. Constipation in Patients With Symptoms of Gastroparesis: Analysis of Symptoms and Gastrointestinal Transit. Clin Gastroenterol Hepatol 2020. - PMC - PubMed
    1. Parkman HP, Yates K, Hasler WL, et al. Similarities and differences between diabetic and idiopathic gastroparesis. Clin Gastroenterol Hepatol 2011;9:1056–64; quiz e133-4. - PMC - PubMed
    1. Hasler WL, Wilson LA, Nguyen LA, et al. Opioid Use and Potency Are Associated With Clinical Features, Quality of Life, and Use of Resources in Patients With Gastroparesis. Clin Gastroenterol Hepatol 2019;17:1285–1294 e1. - PMC - PubMed

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