Autoimmune hepatitis: Challenges and novelties

Abstract

Autoimmune hepatitis is a chronic inflammatory disease of the liver. The etiology is partly unknown and commonly affects women of all ages. It is characterized by increase in transaminase and immunoglobulin G levels, autoantibodies, and portal inflammatory infiltrate with interface hepatitis in the liver biopsy. The treatment is based on the combination of corticoids and azathioprine, but 20-40% of patients require second- or third-line therapies due to intolerance or insufficient response. Here, we will revise the most important aspects regarding the diagnosis and treatment of autoimmune hepatitis emphasizing the challenges faced in clinical practice.

Keywords: Acute autoimmune hepatitis; Antibodies; Anticuerpos; Autoimmune hepatitis; Daño hepático por fármacos; Drug-induced liver injury; Hepatitis autoinmune; Hepatitis autoinmune aguda; Tratamiento; Treatment.