Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Aug;40(8):2017-2023.
doi: 10.1007/s00345-022-04065-5. Epub 2022 Jun 10.

Prostate cancer upgrading and adverse pathology in Hispanic men undergoing radical prostatectomy

Helen Y Hougen  1 , Oleksii A Iakymenko  2 , Sanoj Punnen  3   4   5 , Chad R Ritch  3   4   5 , Bruno Nahar  3   4   5 , Dipen J Parekh  3   4   5 , Oleksandr N Kryvenko  3   2   4   5 , Mark L Gonzalgo  3   4   5
Affiliations

Prostate cancer upgrading and adverse pathology in Hispanic men undergoing radical prostatectomy

Helen Y Hougen et al. World J Urol. 2022 Aug.

Abstract

Purpose: Radical prostatectomy (RP) outcomes in Hispanic men with prostate cancer are not well-described. Prior studies showed varying results regarding the rate of upgrading and upstaging, and these studies included limited pathologic data and lack of central pathology review. We characterized the rate of upgrading, adverse pathology, and oncologic outcomes in Hispanics after prostatectomy using a large institutional database.

Methods: We included Hispanic white (HW), non-Hispanic white (NHW), and black men who underwent (RP) between 2010 and 2021 at a single institution. We recorded differences in grade group between biopsy and prostatectomy and performed multivariable analyses for odds of upgrading and adverse pathologic findings. The primary outcome was rate of upgrading in HWs. Using a sub-cohort with follow-up data, we assessed race/ethnicity and upgrading as a predictor of biochemical recurrence (BCR)-free survival.

Results: Our cohort included 1877 men: 36.7% were NHW, 40.6% were HW, and 22.7% were black. Rates of upgrading were not different between NHW, NHW, and black men at 34.0, 33.8, and 37.3%, respectively (p = 0.4). In the multivariable analysis for upgrading, significant predictors for upgrading were older age (p = 0.002), higher PSA (p < 0.001), and lower prostate weight (p = 0.02), but race/ethnicity did not predict upgrading. In patients with available follow-up (1083, 58%), upgrading predicted worse BCR-free survival (HR 2.17, CI 1.46-3.22, p < 0.0001) but race/ethnicity did not.

Conclusions: HW men undergoing RP had similar rates of upgrading and adverse pathologic outcomes as NHW men. Race/ethnicity does not independently predict upgrading or worse oncologic outcomes after RP.

Keywords: African Americans; Healthcare disparities; Hispanic Americans; Prostatic neoplasms.

PubMed Disclaimer

References

    1. Vespa J, Medina L, Armstrong D (2020) Demographic turning points for the United States: population projections for 2020 to 2060. Curr Popul Reports, US Census Bureau. P25-1144:1–15
    1. Kryvenko ON, Lyapichev K, Chinea FM et al (2016) Radical prostatectomy findings in white Hispanic/Latino men with NCCN very low-risk prostate cancer detected by template biopsy. Am J Surg Pathol 40:1125–1132 - DOI
    1. Guerrios-Rivera L, Howard LE, Klaassen Z et al (2021) Do Hispanic men have worse outcomes after radical prostatectomy? results from SEARCH. Urology 149:181–186. https://doi.org/10.1016/j.urology.2020.10.043 - DOI - PubMed
    1. Nocera L, Wenzel M, Ruvolo CC et al (2021) The impact of race/ethnicity on upstaging and/or upgrading rates among intermediate risk prostate cancer patients treated with radical prostatectomy. World J Urol. https://doi.org/10.1007/s00345-021-03816-0 - DOI - PubMed - PMC
    1. Benjamins MR, Hunt BR, Raleigh SM et al (2016) Racial disparities in prostate cancer mortality in the 50 largest US cities. Cancer Epidemiol 44:125–131. https://doi.org/10.1016/j.canep.2016.07.019 - DOI - PubMed

Substances

LinkOut - more resources