Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2023 Jan;28(1):241-248.
doi: 10.1007/s10741-022-10250-w. Epub 2022 Jun 10.

Clinical outcomes of implantable cardioverter-defibrillator therapy in noncompaction cardiomyopathy: a systematic review and meta-analysis

Martijn Tukker  1 , Arend F L Schinkel  1 , Adem Dereci  1 , Kadir Caliskan  2
Affiliations
Meta-Analysis

Clinical outcomes of implantable cardioverter-defibrillator therapy in noncompaction cardiomyopathy: a systematic review and meta-analysis

Martijn Tukker et al. Heart Fail Rev. 2023 Jan.

Abstract

A subgroup of patients with noncompaction cardiomyopathy (NCCM) is at increased risk of ventricular arrhythmias and sudden cardiac death (SCD). In selected patients with NCCM, implantable cardioverter-defibrillator (ICD) therapy could be advantageous for preventing SCD. Currently, there is no complete overview of outcome and complications after ICD therapy in patients with NCCM. This study sought to present an overview using pooled data of currently available studies. Embase, MEDLINE, Web of Science, and Cochrane databases were searched and returned 915 studies. After a thorough examination, 12 studies on outcome and complications after ICD therapy in patients with NCCM were included. There were 275 patients (mean age 38.6 years; 47% women) with NCCM and ICD implantation. Most of the patients received an ICD for primary prevention (66%). Pooled analysis demonstrates that the appropriate ICD intervention rate was 11.95 per 100 person-years and the inappropriate ICD intervention rate was 4.8 per 100 person-years. The cardiac mortality rate was 2.37 per 100 person-years. ICD-related complications occurred in 10% of the patients, including lead malfunction and revision (4%), lead displacement (3%), infection (2%), and pneumothorax (2%). Patients with NCCM who are at increased risk of SCD may significantly benefit from ICD therapy, with a high appropriate ICD therapy rate of 11.95 per 100 person-years and a low cardiac mortality rate of 2.37 per 100 person-years. Inappropriate therapy rate of 4.8 per 100 person-years and ICD-related complications were not infrequent and may lead to patient morbidity.

Keywords: Appropriate ICD treatment; Implantable cardioverter-defibrillator (ICD); Mortality; Noncompaction cardiomyopathy; Sudden cardiac death; Systematic review and meta-analysis.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
PRISMA flowchart of the literature search and study selection
Fig. 2
Fig. 2
Forest plot of appropriate ICD therapies per 100 person-years in NCCM patients
Fig. 3
Fig. 3
Forest plot of inappropriate ICD therapies per 100 person-years in NCCM patients
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Oechslin EN, Attenhofer Jost CH, Rojas JR, Kaufmann PA, Jenni R (2002) Long-term follow-up of 34 adults with isolated left ventricular noncompaction: a distinct cardiomyopathy with poor prognosis. J Am Coll Cardiol 36:493–500, Aug 2000. 10.1016/s0735-1097(00)00755-5 - PubMed
    1. Weiford BC, Subbarao VD, Mulhern KM. Noncompaction of the ventricular myocardium. Circulation. 2004;109(24):2965–2971. doi: 10.1161/01.CIR.0000132478.60674.D0. - DOI - PubMed
    1. van Waning JI, et al. Genetics, clinical features, and long-term outcome of noncompaction cardiomyopathy. J Am Coll Cardiol. 2018;71(7):711–722. doi: 10.1016/j.jacc.2017.12.019. - DOI - PubMed
    1. Gati S, Papadakis M, Van Niekerk N, Reed M, Yeghen T, Sharma S. Increased left ventricular trabeculation in individuals with sickle cell anaemia: physiology or pathology? Int J Cardiol. 2013;168(2):1658–1660. doi: 10.1016/j.ijcard.2013.03.039. - DOI - PubMed
    1. Caliskan OISK, ten Cate FJ, editors. Noncompaction cardiomyopathy. Cham: Springer; 2019.