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. 2022 Oct;70(10):2764-2774.
doi: 10.1111/jgs.17921. Epub 2022 Jun 11.

AGS and NIA bench-to bedside conference summary: Cancer and cardiovascular disease

Supriya Mohile  1 , Caroline S Blaum  2 , Peter M Abadir  3 , William Dale  4 , Daniel E Forman  5 , Chunkit Fung  1 , Holly M Holmes  6 , Javid Moslehi  7 , Karen M Mustian  1 , Michael W Rich  8 , Heather E Whitson  9   10
Affiliations

AGS and NIA bench-to bedside conference summary: Cancer and cardiovascular disease

Supriya Mohile et al. J Am Geriatr Soc. 2022 Oct.

Abstract

This report summarizes the presentations, discussions, and recommendations of the most recent American Geriatrics Society and National Institute on Aging research conference, "Cancer and Cardiovascular Disease," on October 18-19, 2021. The purpose of this virtual meeting was to address the interface between cancer and heart disease, which are the two leading causes of death among older Americans. Age-related physiologic changes are implicated in the pathogenesis of both conditions. Emerging data suggest that cancer-related cardiovascular disease (CVD) involves disrupted cell signaling and cellular senescence. The risk factors for CVD are also risk factors for cancer and an increased likelihood of cancer death, and people who have both cancer and CVD do more poorly than those who have only cancer or only CVD. Issues addressed in this bench-to-bedside conference include mechanisms of cancer and CVD co-development in older adults, cardiotoxic effects of cancer therapy, and management of comorbid cancer and CVD. Presenters discussed approaches to ensure equitable access to clinical trials and health care for diverse populations of adults with CVD and cancer, mechanisms of cancer therapy cardiotoxicity, and management of comorbid CVD and cancer, including the role of patient values and preferences in treatment decisions. Workshop participants identified many research gaps and questions that could lead to an enhanced understanding of comorbid CVD and cancer and to better and more equitable management strategies.

Keywords: aging; cancer; cardiotoxicity; cardiovascular disease.

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Conflict of interest statement

Conflicts of Interest

JM has served on advisory boards for Pfizer, Novartis, Bristol-Myers Squibb, Deciphera, Audentes Pharmaceuticals, Takeda, Myokardia, AstraZeneca, GlaxoSmithKline, Boston Biomedical, ImmunoCore, Janssen, Myovant, Silverback Therapeutics, Amgen, Kurome Therapeutics, Kiniska Pharmaceuticals, Daiichi Sankyo, CRC Oncology, BeiGene, Star Therapeutics, ProteinQure, Pharmacyclics, Mallinckrodt Pharmaceuticals, Boehringer, and Cytokinetics, and is supported by is supported by National Institutes of Health grants (R01HL141466, R01HL155990, R01HL156021). HMH is funded by Healthcare Services Corporation (Blue Cross/Blue Shield), the National Institute on Aging, and the National Center to Advance Translational Sciences. SM, CB, HEW, PMA, WD, DEF, CF, KMM, and MWR have no conflicts to report.

Figures

Figure 1.
Figure 1.. Cardio-Oncology Priorities from a Geriatrics Perspective
Adapted from Lenihan DJ, Fradley MG, Dent S, et al. Proceedings from the Global Cardio-Oncology Summit: The top 10 priorities to actualize for CardioOncology. JACC CardioOncol Dec 2019;1(2):256–272. doi:10.1016/j.jaccao.2019.11.007 Abbreviations: CV, cardiovascular; CVD, cardiovascular disease.
See this image and copyright information in PMC

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