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Review
. 2022 Jul;126(1):168-174.
doi: 10.1002/jso.26931.

Surgery or active surveillance for pNETs < 2 cm: Preliminary results from a single center Brazilian cohort

Dante A S M Arra  1 , Heber S C Ribeiro  1 , Gustavo Henklain  1 , Alex Barbosa  1 , Silvio M Torres  1 , Alessandro L Diniz  1 , André L Godoy  1 , Igor C Farias  1 , Wilson L Costa Jr  1   2 , Felipe J F Coimbra  1
Affiliations
Review

Surgery or active surveillance for pNETs < 2 cm: Preliminary results from a single center Brazilian cohort

Dante A S M Arra et al. J Surg Oncol. 2022 Jul.

Abstract

Background and objectives: Incidence of pancreatic neuroendocrine tumors (pNETS) seems to be rising over the years, with many cases incidentally diagnosed. Surgery and active surveillance are current treatment modalities for small pNETS. We review our institutional series and compare outcomes for small asymptomatic and nonfunctioning tumors.

Methods: This retrospective cohort study included patients with 2 cm or less and well differentiated pNETS at a single Brazilian Cancer Center. From 2002 to 2020, patients received active surveillance or surgery as a treatment strategy. Short and long-term results were compared.

Results: Sixty-four patients were included, 41 in surgical strategy and 23 in the active surveillance approach. Baseline group characteristics were comparable. More patients on active surveillance underwent abdominal magnetic resonance imaging (MRI) and had tumors located in the pancreatic head (41% vs. 17%, p = 0.038). Minimally invasive procedure was chosen in 80.1% of the surgical patients. No patient died after surgery. Median follow-up period was 38.6 and 46.4 months for active surveillance and surgery cohorts, respectively. No difference in disease progression rate was observed.

Conclusion: Both approaches seem to be safe for small pNETs. Long-term outcome and quality of life should be considered when discussing such options with patients.

Keywords: active surveillance; pancreatic neuroendocrine tumors; surgery.

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References

REFERENCES

    1. Verbeke C, Caroline SV, Fiona C, et al. Pathology of the pancreas: a practical approach. Springer Verlag; 2013.
    1. Howe JR, Merchant NB, Conrad C, et al. The North American Neuroendocrine Tumor Society consensus paper on the surgical management of pancreatic neuroendocrine tumors. Pancreas. 2020;49:1-33.
    1. Hayward R. Personal view: VOMIT (victims of modern imaging technology)-an acronym for our times. BMJ. 2003;326:1273.
    1. Partelli S, Cirocchi R, Crippa S, et al. Systematic review of active surveillance versus surgical management of asymptomatic small non-functioning pancreatic neuroendocrine neoplasms. Vol 10. Oxford Academic; 2017:1002.
    1. Sallinen V, Le Large TYS, Galeev S, et al. Surveillance strategy for small asymptomatic non-functional pancreatic neuroendocrine tumors-a systematic review and meta-analysis. HPB. 2017;19:310-320.

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