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Review
. 2022 Aug:77:102217.
doi: 10.1016/j.coi.2022.102217. Epub 2022 Jun 8.

Tissue-specific proteasomes in generation of MHC class I peptides and CD8+ T cells

Mami Matsuda-Lennikov  1 , Izumi Ohigashi  2 , Yousuke Takahama  3
Affiliations
Review

Tissue-specific proteasomes in generation of MHC class I peptides and CD8+ T cells

Mami Matsuda-Lennikov et al. Curr Opin Immunol. 2022 Aug.

Abstract

Thymoproteasomes and immunoproteasomes are two types of tissue-specific proteasomes, which contribute to the production of major histocompatibility complex (MHC) class I (MHC-I)-associated peptides that are important for the development and function of CD8+ cytotoxic T cells. Thymoproteasomes are specifically expressed by cortical thymic epithelial cells and are important for MHC-I-dependent positive selection of developing thymocytes, whereas immunoproteasomes are abundant in many other cells, including hematopoietic cells and medullary thymic epithelial cells. Here we summarize the role of these two tissue-specific proteasomes, focusing on their functions in the development of CD8+ T cells in the thymus.

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Conflict of interest statement

Declaration of Competing Interest

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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