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Comment
. 2022 Jun 10;3(6):353-354.
doi: 10.1016/j.medj.2022.05.009.

CAR T cell therapy for solid tumors: Fatal attraction requires adhesion

Matthew Bell  1 , Stephen Gottschalk  2
Affiliations
Free article
Comment

CAR T cell therapy for solid tumors: Fatal attraction requires adhesion

Matthew Bell et al. Med. .
Free article

Abstract

Chimeric antigen receptor (CAR) T cell therapy has shown limited efficacy against solid tumors in clinical studies in contrast to hematological malignancies. In a paper recently published in Nature, Larson et al. report that CAR T cell activity against solid tumors depends on cell adhesion mediated by IFNγ signaling, opening the prospect of improving their clinical activity in the future.

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Conflict of interest statement

Declaration of interests M.B. and S.G. have patent applications in the fields of cell and/or gene therapy for cancer. S.G. is a consultant of TESSA Therapeutics, a DSMB member of Immatics, and has received honoraria from Tidal, Catamaran Bio, Sanofi, and Novartis within the last 2 years. None of these relationships conflict with the published work.

Comment on

  • CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours.
    Larson RC, Kann MC, Bailey SR, Haradhvala NJ, Llopis PM, Bouffard AA, Scarfó I, Leick MB, Grauwet K, Berger TR, Stewart K, Anekal PV, Jan M, Joung J, Schmidts A, Ouspenskaia T, Law T, Regev A, Getz G, Maus MV. Larson RC, et al. Nature. 2022 Apr;604(7906):563-570. doi: 10.1038/s41586-022-04585-5. Epub 2022 Apr 13. Nature. 2022. PMID: 35418687

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