Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 Jun 10;3(6):358-360.
doi: 10.1016/j.medj.2022.05.013.

Quiescent cancer cells: Therapeutic targets to overcome immunotherapy resistance?

Leisha A Emens  1 , Ashley Cimino-Mathews  2
Affiliations
Free article
Comment

Quiescent cancer cells: Therapeutic targets to overcome immunotherapy resistance?

Leisha A Emens et al. Med. .
Free article

Abstract

Triple-negative breast cancer (TNBC) is a heterogeneous disease with poor clinical outcomes. Chemoimmunotherapy improves outcomes in high-risk, early-stage disease, but not all patients benefit. Baldominos and colleagues1 drill down into early TNBC sub-microenvironments using single-cell technologies, characterizing quiescent cancer cell niches that may drive immunotherapy resistance and disease relapse.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests LAE has participated on advisory boards and/or received consulting fees from Genentech, F Hoffman La Roche, Chugai, GPCR, Gilead, Immutep, Immune Onc, Mersana, and Shionogi; she has received royalties from Aduro Biotech. LAE has participated on the steering committee for IMpassion130, KATE2, and KATE3. She is the current Vice President of the Society for the Immunotherapy of Cancer. ACM has received consulting fees from Bristol-Myers Squibb and Roche.

Comment on

  • Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche.
    Baldominos P, Barbera-Mourelle A, Barreiro O, Huang Y, Wight A, Cho JW, Zhao X, Estivill G, Adam I, Sanchez X, McCarthy S, Schaller J, Khan Z, Ruzo A, Pastorello R, Richardson ET, Dillon D, Montero-Llopis P, Barroso-Sousa R, Forman J, Shukla SA, Tolaney SM, Mittendorf EA, von Andrian UH, Wucherpfennig KW, Hemberg M, Agudo J. Baldominos P, et al. Cell. 2022 May 12;185(10):1694-1708.e19. doi: 10.1016/j.cell.2022.03.033. Epub 2022 Apr 20. Cell. 2022. PMID: 35447074 Free PMC article.

Publication types

LinkOut - more resources