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Comment
. 2022 Jul;19(7):855-857.
doi: 10.1038/s41423-022-00875-0. Epub 2022 Jun 11.

The disruption of intestinal homeostasis when foods are colored red

Wenjing Yang  1 , Yingzi Cong  2
Affiliations
Comment

The disruption of intestinal homeostasis when foods are colored red

Wenjing Yang et al. Cell Mol Immunol. 2022 Jul.
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Red 40 induces colitis. Red 40 induces colitis in the context of dysregulated IL-23 expression through the induction of IFNγ+ CD4+ cytotoxic T cells, which cause IEC apoptosis
See this image and copyright information in PMC

Comment on

References

    1. Chen L, He Z, Reis BS, Gelles JD, Chipuk JE, Ting AT, et al. IFNγ+ cytotoxic CD4+ T lymphocytes are involved in the pathogenesis of colitis induced by IL-23 and food colorant Red 40. Cell Mol Immunol. 2022;19:777–90. - DOI - PMC - PubMed
    1. Elson CO, Cong Y. Host-microbiota interactions in inflammatory bowel disease. Gut Microbes. 2012;3:332–44. - DOI - PMC - PubMed
    1. Huang H, Fang M, Jostins L, Umicevic Mirkov M, Boucher G, Anderson CA, et al. Fine-mapping inflammatory bowel disease loci to single-variant resolution. Nature. 2017;547:173–8. - DOI - PMC - PubMed
    1. Bamias G, Cominelli F. Cytokines and intestinal inflammation. Curr Opin Gastroenterol. 2016;32:437–42. - DOI - PubMed
    1. Cua DJ, Sherlock J, Chen Y, Murphy CA, Joyce B, Seymour B, et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature. 2003;421:744–8. - DOI - PubMed