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. 2022 Jun 11;15(1):202.
doi: 10.1186/s13104-022-06088-y.

Challenges and solutions to recruitment of neonates and children having cardiac surgery into a study using a novel sampling device

Terrie Walker-Smith  1 , Daniel Fudulu  2   3 , Aravind Ramesh  2   3 , Karen Sheehan  3 , Julie Madden  3 , Lucy Culliford  1 , Jonathan Evans  1 , Gianni D Angelini  2   3 , Thomas Upton  3   4 , Ben Gibbison  5   6   7
Affiliations

Challenges and solutions to recruitment of neonates and children having cardiac surgery into a study using a novel sampling device

Terrie Walker-Smith et al. BMC Res Notes. .

Erratum in

Abstract

Objective: To narratively describe the challenges and solutions required in delivering a non-commercial study of children undergoing cardiac surgery using a novel subcutaneous hormone collection device.

Results: The challenges faced by the research team are divided into those of conducting healthcare research in children and those specific to this study. Many of the issues of conducting healthcare research in children can and have been overcome by structural and institutional culture change-normalising and embedding research as part of good clinical care. The issues specific to insertion and maintenance of the novel collection device can be overcome by education and support of the clinical teams. The increased incentives and resources of commercial research may have overcome many of these.

Keywords: Adrenal; Cardiac surgery; Hypothalamic-pituitary-adrenal axis; Paediatric endocrinology.

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Conflict of interest statement

The authors have no Competing of interest to declare.

Figures

Fig. 1
Fig. 1
“The prototype microdialysis sample collector “U-RHYTHM” in use on a child who has recently undergone cardiac surgery. Fluid collected using a CE-marked clinical microdialysis probe (mDialysis, Sweden) is collected and automatically fractioned into samples which are stored in the U-RHYTHM device until the end of the sampling procedure, prior to retrieval and analysis (reproduced from [2])
See this image and copyright information in PMC

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