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. 2022 Jul;22(7):943-945.
doi: 10.1016/S1473-3099(22)00362-0. Epub 2022 Jun 9.

Immune responses after omicron infection in triple-vaccinated health-care workers with and without previous SARS-CoV-2 infection

Kim Blom  1 , Ulrika Marking  2 , Sebastian Havervall  2 , Nina Greilert Norin  2 , Max Gordon  2 , Marina García  3 , Teghesti Tecleab  4 , Wanda Christ  5 , Mattias Forsell  6 , Mia Phillipson  7 , Peter Nilsson  8 , Sara Mangsbo  9 , Sophia Hober  8 , Mikael Åberg  10 , Jonas Klingström  3 , Charlotte Thålin  11
Affiliations

Immune responses after omicron infection in triple-vaccinated health-care workers with and without previous SARS-CoV-2 infection

Kim Blom et al. Lancet Infect Dis. 2022 Jul.
No abstract available

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Conflict of interest statement

We declare no competing interests. KB, UM, SHa, JK, and CT contributed equally. This research was funded by grants from the Knut and Alice Wallenberg Foundation (to CT and JK), the Jonas and Kristina af Jochnick Foundation (to CT), the Leif Lundblad Family Foundation (to CT), Region Stockholm (to CT), and Center for Innovative Medicine (to KB and JK).

Figures

Figure
Figure
Immune responses following omicron BTI in triple-vaccinated health-care workers with and without prior SARS-CoV-2 infection (A) GMTs (with 95% CIs) of anti-wildtype spike IgG at baseline and up to 5 weeks post-omicron BTI in participants without (n=20) and with (n=10) previous SARS-CoV-2 infection. The grey dots and dashed line represent participants who remained qPCR negative throughout the study period (n=69). (B) T-cell responses against SARS-CoV-2 S1 protein in participants without omicron BTI and 7 weeks post-infection in participants with omicron BTI; participants had no history of SARS-CoV-2 infection. Individual-participant data (dots) and GMTs (with 95% CIs; lines) are shown. (C) GMTs (with 95% CIs) of anti-spike IgG against wildtype, delta, and omicron BA.1 and BA.2 variants at baseline and 7 weeks after omicron BTI in participants without (n=40) and with (n=16) previous SARS-CoV-2 infection. (D) T-cell responses against SARS-CoV-2 S1 protein in participants without omicron BTI and 7 weeks post-infection in participants with omicron BTI; participants had a history of SARS-CoV-2 infection. Individual-participant data (dots) and GMTs (with 95% CIs; lines) are shown. BTI=breakthrough infection. GMT=geometric mean titre. ns=not significant. SFU=spot-forming units. *p<0·001. †p<0·01. ‡p<0·0001.
See this image and copyright information in PMC

References

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