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Editorial
. 2022 Jun;11(3):415-418.
doi: 10.21037/hbsn-21-557.

Neutrophil extracellular traps contribute to the development of hepatocellular carcinoma in NASH by promoting Treg differentiation

Rallia-Iliana Velliou  1 , Ioannis Mitroulis  2   3 , Antonios Chatzigeorgiou  1   3
Affiliations
Editorial

Neutrophil extracellular traps contribute to the development of hepatocellular carcinoma in NASH by promoting Treg differentiation

Rallia-Iliana Velliou et al. Hepatobiliary Surg Nutr. 2022 Jun.
No abstract available

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://hbsn.amegroups.com/article/view/10.21037/hbsn-21-557/coif). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
During Nonalcoholic steatohepatitis (NASH), neutrophil extracellular traps (NETs) enable the crosstalk between innate and adaptive immunity by promoting T regulatory cell (Treg) proliferation and activity. As a result, the Treg subpopulation selectively increases in the course of NASH and continues to do so during the transition to Hepatocellular carcinoma (HCC). As a result, immune surveillance is impaired along with a decrease in both CD4+IFN-γ+ and TNF-secreting CD8+ cells.
See this image and copyright information in PMC

Comment on

References

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