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Review
. 2022 May 26:13:907287.
doi: 10.3389/fimmu.2022.907287. eCollection 2022.

Avian Leucosis Virus-Host Interaction: The Involvement of Host Factors in Viral Replication

Shuang Tang  1 , Jie Li  2 , Yung-Fu Chang  2 , Wencheng Lin  1
Affiliations
Review

Avian Leucosis Virus-Host Interaction: The Involvement of Host Factors in Viral Replication

Shuang Tang et al. Front Immunol. .

Abstract

Avian leukosis virus (ALV) causes various diseases associated with tumor formation and decreased fertility. Moreover, ALV induces severe immunosuppression, increasing susceptibility to other microbial infections and the risk of failure in subsequent vaccination against other diseases. There is growing evidence showing the interaction between ALV and the host. In this review, we will survey the present knowledge of the involvement of host factors in the important molecular events during ALV infection and discuss the futuristic perspectives from this angle.

Keywords: avian leukemia virus; host factors; immunosuppression; interaction; replication.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

    1. Salter D, Balander R, Crittenden L. Evaluation of Japanese Quail as a Model System for Avian Transgenesis Using Avian Leukosis Viruses. Poultry Sci (1999) 78:230–4. doi: 10.1093/ps/78.2.230 - DOI - PubMed
    1. Feng W, Zhou D, Meng W, Li G, Zhuang P, Pan Z, et al. Growth Retardation Induced by Avian Leukosis Virus Subgroup J Associated With Down-Regulated Wnt/β-Catenin Pathway. Microbial Pathogene (2017) 104:48–55. doi: 10.1016/j.micpath.2017.01.013 - DOI - PubMed
    1. Wang Q, Miao Y, Xu Y, Meng X, Cui W, Wang Y, et al. Taishan Pinus Massoniana Pollen Polysaccharide Inhibits the Replication of Acute Tumorigenic ALV-J and Its Associated Tumor Growth. Vet Microbiol (2019) 236:108376. doi: 10.1016/j.vetmic.2019.07.028 - DOI - PubMed
    1. Zhang Q, Xie T, Mo G, Zhang Z, Lin L, Zhang X. ACSL1 Inhibits ALV-J Replication by IFN-I Signaling and PI3K/Akt Pathway. Front Immunol (2021) 12:774323. doi: 10.3389/fimmu.2021.774323 - DOI - PMC - PubMed
    1. Tsukamoto K, Hasebe M, Kakita S, Taniguchi Y, Hihara H, Kono Y. Sporadic Congenital Transmission of Avian Leukosis Virus in Hens Discharging the Virus Into the Oviducts. J Vet Med Sci (1992) 54:99–103. doi: 10.1292/jvms.54.99 - DOI - PubMed

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