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. 2023 Jan;160(1):150-160.
doi: 10.1002/ijgo.14306. Epub 2022 Jul 11.

First-trimester screening for pre-eclampsia and small for gestational age: A comparison of the gaussian and Fetal Medicine Foundation algorithms

Berta Serrano  1 , Erika Bonacina  1 , Carlota Rodo  1 , Pablo Garcia-Manau  1 , María Ángeles Sanchez-Duran  1 , María Pancorbo  1 , Cristina Forcada  1 , María Teresa Murcia  1 , Ana Perestelo  1 , Mireia Armengol-Alsina  1 , Manel Mendoza  1 , Elena Carreras  1
Affiliations

First-trimester screening for pre-eclampsia and small for gestational age: A comparison of the gaussian and Fetal Medicine Foundation algorithms

Berta Serrano et al. Int J Gynaecol Obstet. 2023 Jan.

Abstract

Objective: Pre-eclampsia (PE) and small for gestational age (SGA) can be predicted from the first trimester. The most widely used algorithm worldwide is the Fetal Medicine Foundation (FMF) algorithm. The recently described Gaussian algorithm has reported excellent results although it is unlikely to be externally validated. Therefore, as an alternative approach, we compared the predictive accuracy for PE and SGA of the Gaussian and FMF algorithms.

Methods: Secondary analysis of a prospective cohort study was conducted at Vall d'Hebron University Hospital (Barcelona) with 2641 singleton pregnancies. The areas under the curve for the predictive performance for early-onset and preterm PE and early-onset and preterm SGA were calculated with the Gaussian and FMF algorithms and subsequently compared.

Results: The FMF and Gaussian algorithms showed a similar predictive performance for most outcomes and marker combinations. Nevertheless, significant differences for early-onset PE prediction favored the Gaussian algorithm in the following combinations: mean arterial blood pressure (MAP) with pregnancy-associated plasma protein A, MAP with placental growth factor, and MAP alone.

Conclusions: The first-trimester Gaussian and FMF algorithms have similar performances for PE and SGA prediction when applied with all markers within a routine care setting in a Spanish population, adding evidence to the external validity of the FMF algorithm.

Keywords: PlGF; early-onset pre-eclampsia; first trimester; pre-eclampsia; screening; uterine artery doppler.

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Conflict of interest statement

Manel Mendoza, MD, PhD, received lecture fees by Roche diagnostics. The other authors report no conflicts of interest.

References

    1. Tan MY, Syngelaki A, Poon LC, et al. Screening for pre‐eclampsia by maternal factors and biomarkers at 11–13 weeks' gestation. Ultrasound Obstet Gynecol. 2018;52:186‐195. - PubMed
    1. Tan MY, Poon LC, Rolnik DL, et al. Prediction and prevention of small‐for‐gestational‐age neonates: evidence from SPREE and ASPRE. Ultrasound Obstet Gynecol. 2018;52:52‐59. - PubMed
    1. Serra B, Mendoza M, Scazzocchio E, et al. A new model for screening for early‐onset preeclampsia. Am J Obstet Gynecol. 2020;222:608.e1‐608.e18. - PubMed
    1. Mendoza M, Serrano B, Bonacina E, et al. Diagnostic accuracy of the gaussian first‐trimester combined screening for pre‐eclampsia to predict small‐for‐gestational‐age neonates. Int J Gynaecol Obstet. 2022;156:322‐330. - PubMed
    1. Mendoza M, Tur H, Garcia‐Manau P, et al. Cut‐off values for gaussian first‐trimester screening for early‐onset preeclampsia with maternal history, biochemical markers and uterine artery doppler. J Gynecol Obstet Hum Reprod. 2021;50:101827. - PubMed