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Editorial
. 2022 Jun 14;145(24):1780-1783.
doi: 10.1161/CIRCULATIONAHA.122.059935. Epub 2022 Jun 13.

At the Crossroad Between Skeletal and Cardiac Muscle Cells

Christopher R deFilippi  1 , Abdulla A Damluji  1   2
Affiliations
Editorial

At the Crossroad Between Skeletal and Cardiac Muscle Cells

Christopher R deFilippi et al. Circulation. .
No abstract available

Keywords: Editorials; biomarkers; muscle, skeletal; myocardium; troponin.

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Figures

Figure 1.
Figure 1.
Adults with pre-frailty, frailty or others with co-morbidities may have skeletal muscle loss or disorders that could result in cTnT production (left panel). Circulating cTnT, but not cTnI is measurable by high sensitivity assays in patients without known cardiovascular disease, but skeletal myopathy or myositis (from du Fay de Lavallaz et al.) (middle panel). Prior longitudinal ambulatory studies show that both cTnI and cTnT levels are long-term prognosticators for incident heart failure, but hs-cTnI is more prognostic of incident MI (right panel). cTnI, cardiac troponin I; cTnT, cardiac troponin T; hs, high sensitivity; ULN, upper limit of normal (defined as the 99th percentile value in a healthy adult population).
See this image and copyright information in PMC

Comment on

  • Skeletal Muscle Disorders: A Noncardiac Source of Cardiac Troponin T.
    du Fay de Lavallaz J, Prepoudis A, Wendebourg MJ, Kesenheimer E, Kyburz D, Daikeler T, Haaf P, Wanschitz J, Löscher WN, Schreiner B, Katan M, Jung HH, Maurer B, Hammerer-Lercher A, Mayr A, Gualandro DM, Acket A, Puelacher C, Boeddinghaus J, Nestelberger T, Lopez-Ayala P, Glarner N, Shrestha S, Manka R, Gawinecka J, Piscuoglio S, Gallon J, Wiedemann S, Sinnreich M, Mueller C; BASEL XII Investigators. du Fay de Lavallaz J, et al. Circulation. 2022 Jun 14;145(24):1764-1779. doi: 10.1161/CIRCULATIONAHA.121.058489. Epub 2022 Apr 7. Circulation. 2022. PMID: 35389756 Free PMC article.

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