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Comment
. 2022 Aug;21(8):676-677.
doi: 10.1016/S1474-4422(22)00234-4. Epub 2022 Jun 10.

The importance of genomics in advancing the diagnosis and treatment of dementia

Boris Decourt  1 , Marwan N Sabbagh  2
Affiliations
Comment

The importance of genomics in advancing the diagnosis and treatment of dementia

Boris Decourt et al. Lancet Neurol. 2022 Aug.
No abstract available

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Conflict of interest statement

MNS discloses ownership interest (stock or stock options) in Cortexyme, EIP Pharma, NeuroTau, Optimal Cognitive Health Company, uMETHOD, Athira Pharma, TransDermix, and Cognoptix; and receives consultancy fees from Alzheon, Biogen, Genentech (Roche Group), Acadia Pharmaceuticals, T3D Therapeutics, Eisai, Eli Lilly, KeifeRx, and NeuroTherapia. BD declares no competing interests. The work of MNS and BD is financially supported by National Institutes of Health grants (R01AG059008, P30AG072980, and R01AG073212).

Comment on

  • A human brain vascular atlas reveals diverse mediators of Alzheimer's risk.
    Yang AC, Vest RT, Kern F, Lee DP, Agam M, Maat CA, Losada PM, Chen MB, Schaum N, Khoury N, Toland A, Calcuttawala K, Shin H, Pálovics R, Shin A, Wang EY, Luo J, Gate D, Schulz-Schaeffer WJ, Chu P, Siegenthaler JA, McNerney MW, Keller A, Wyss-Coray T. Yang AC, et al. Nature. 2022 Mar;603(7903):885-892. doi: 10.1038/s41586-021-04369-3. Epub 2022 Feb 14. Nature. 2022. PMID: 35165441 Free PMC article.
  • New insights into the genetic etiology of Alzheimer's disease and related dementias.
    Bellenguez C, Küçükali F, Jansen IE, Kleineidam L, Moreno-Grau S, Amin N, Naj AC, Campos-Martin R, Grenier-Boley B, Andrade V, Holmans PA, Boland A, Damotte V, van der Lee SJ, Costa MR, Kuulasmaa T, Yang Q, de Rojas I, Bis JC, Yaqub A, Prokic I, Chapuis J, Ahmad S, Giedraitis V, Aarsland D, Garcia-Gonzalez P, Abdelnour C, Alarcón-Martín E, Alcolea D, Alegret M, Alvarez I, Álvarez V, Armstrong NJ, Tsolaki A, Antúnez C, Appollonio I, Arcaro M, Archetti S, Pastor AA, Arosio B, Athanasiu L, Bailly H, Banaj N, Baquero M, Barral S, Beiser A, Pastor AB, Below JE, Benchek P, Benussi L, Berr C, Besse C, Bessi V, Binetti G, Bizarro A, Blesa R, Boada M, Boerwinkle E, Borroni B, Boschi S, Bossù P, Bråthen G, Bressler J, Bresner C, Brodaty H, Brookes KJ, Brusco LI, Buiza-Rueda D, Bûrger K, Burholt V, Bush WS, Calero M, Cantwell LB, Chene G, Chung J, Cuccaro ML, Carracedo Á, Cecchetti R, Cervera-Carles L, Charbonnier C, Chen HH, Chillotti C, Ciccone S, Claassen JAHR, Clark C, Conti E, Corma-Gómez A, Costantini E, Custodero C, Daian D, Dalmasso MC, Daniele A, Dardiotis E, Dartigues JF, de Deyn PP, de Paiva Lopes K, de Witte LD, Debette S, Deckert J, Del Ser T, Denning N, DeStefano A, Dichgans M,… See abstract for full author list ➔ Bellenguez C, et al. Nat Genet. 2022 Apr;54(4):412-436. doi: 10.1038/s41588-022-01024-z. Epub 2022 Apr 4. Nat Genet. 2022. PMID: 35379992 Free PMC article.

References

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    1. Yang AC, Vest RT, Kern F, et al. A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk. Nature. 2022; 603(7903): 885–92. - PMC - PubMed
    1. Bakken TE, Hodge RD, Miller JA, et al. Single-nucleus and single-cell transcriptomes compared in matched cortical cell types. PLoS One. 2018; 13(12): e0209648. - PMC - PubMed

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