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Case Reports
. 1986 Dec;21(6):633-7.
doi: 10.1007/BF02774493.

A copper-sulfur complex in the liver of a patient with Wilson's disease

A Sasa, H Hayashi, A Yagi, S Ohguchi, R Kidokoro, Y Sato, N Sakamoto
Case Reports

A copper-sulfur complex in the liver of a patient with Wilson's disease

A Sasa et al. Gastroenterol Jpn. 1986 Dec.

Abstract

An asymptomatic 16-year-old boy was found to have Wilson's disease without Kayser-Fleischer rings. Liver biopsy showed chronic active hepatitis with 1025 micrograms copper/g dry weight. After 19 months of d-penicillamine therapy, the liver histology became almost normal and the copper content decreased to 238 micrograms/g dry weight. The liver specimens obtained before and after treatment were studied by X-ray probe microanalysis. After treatment, both copper and sulfur decreased in hepatocellular lysosomes. The estimated molar ratio of the decreased copper to the decreased sulfur was 32/100. These figures suggest that lysosomal copper exists in the form of metallothionein.

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