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. 2022 May;41(3):384-387.
doi: 10.23876/j.krcp.22.029. Epub 2022 May 12.

Successful ABO-incompatible kidney transplantation and SARS-CoV-2-specific immune monitoring in a patient recovered from coronavirus infection

Su Yeon Hong  1   2 , Hyunjoo Bae  3 , Sun Cheol Park  4 , Chul Woo Yang  1   2 , Eun-Jee Oh  5 , Byung Ha Chung  1   2
Affiliations

Successful ABO-incompatible kidney transplantation and SARS-CoV-2-specific immune monitoring in a patient recovered from coronavirus infection

Su Yeon Hong et al. Kidney Res Clin Pract. 2022 May.
No abstract available

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Conflict of interest statement

Conflicts of interest

All authors have no conflicts of interest to declare.

Figures

Figure 1.
Figure 1.. Expression of T cell, NK cell, and Treg subset cytokine as detected by flow cytometry from COVID-19 infection had recovered at 6 weeks after COVID-19 diagnosis.
(A) T cells (CD8+ and CD4+) producing cytokines were detectable in flow cytometry. (B) NK (CD16– CD56+ and CD16+ CD56–) subsets producing cytokines were detectable in flow cytometry. (C) Treg (CD25+ CD127low) subsets producing cytokines were detectable by flow cytometry. Flow cytometry results confirm adaptive immunity toward COVID-19 (SARS-CoV-2) in the case patient. COVID-19, coronavirus disease-19; NK, natural killer; SARS-CoV2, severe acute respiratory syndrome coronavirus 2; Treg, regulatory T cell.
Figure 2.
Figure 2.. Pre- and posttransplant T cell immunity of the patient.
(A) SARS-CoV-2–specific T cell immunity by ELISPOT (spike protein S1, N protein, and M protein). Adaptive immunity to SARS-CoV-2 virus was confirmed by SARS-CoV-2–specific protein (spike protein, N protein, and M protein) detection by the ELISPOT method. After KT, SARS-CoV-2–specific protein level decreased in correlation with flow cytometry results of T cell, Treg, and NK subsets cytokine expression. Decreased adaptive immunity was retained up to 3 months after KT. (B) Adaptive immune response of cytokine expression of T cell, NK and Treg subsets detected by flow cytometry (CD8+, CD4+, NK, and Treg expression). After recovery from COVID-19 infection, our patient showed adaptive immunity toward SARS-CoV-2 before KT, with absolute cell count/3,000 lymphocytes by flow cytometry. T-cell immunity was expressed as CD4+ and CD8+, Treg was expressed as CD25+ CD127low, and the NK subset was expressed as CD16– CD56+ and CD16+ CD56–. The CD8+ and CD4+ absolute cell count decreased at 1 month after KT. The CD8+ absolute cell count abruptly rebounded at 3 months after KT, but CD4+ absolute cell count remained low. Expression of NK and Treg subset also remained low at 3 months after KT. COVID-19, coronavirus disease-19; ELISPOT, enzyme-linked immune absorbent spot; KT, kidney transplant; M, M protein; N, N protein; NK, natural killer; PBMC, peripheral blood mononuclear cell; S1, spike protein; SARS-CoV2, severe acute respiratory syndrome coronavirus 2; Treg, regulatory T cells.
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