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. 2022 Oct;29(10):3017-3027.
doi: 10.1111/ene.15445. Epub 2022 Jun 25.

Neural distinctiveness of fatigue and low sleep quality in multiple sclerosis

Adriana L Ruiz-Rizzo  1   2 , Peter Bublak  2 , Steffen Kluckow  2 , Kathrin Finke  1   2 , Christian Gaser  2 , Matthias Schwab  2 , Daniel Güllmar  2 , Hermann J Müller  1 , Otto W Witte  2 , Sven Rupprecht  2
Affiliations

Neural distinctiveness of fatigue and low sleep quality in multiple sclerosis

Adriana L Ruiz-Rizzo et al. Eur J Neurol. 2022 Oct.

Abstract

Background and purpose: Fatigue and low sleep quality in multiple sclerosis (MS) are closely related symptoms. Here, the associations between the brain's functional connectivity (FC) and fatigue and low sleep quality were investigated to determine the degree of neural distinctiveness of these symptoms.

Method: A hundred and four patients with relapsing-remitting MS (age 38.9 ± 10.2 years, 66 females) completed the Modified Fatigue Impact Scale and the Pittsburgh Sleep Quality Index and underwent resting-state functional magnetic resonance imaging. FC was analyzed using independent-component analysis in sensorimotor, default-mode, fronto-parietal and basal-ganglia networks. Multiple linear regression models allowed us to test the association between FC and fatigue and sleep quality whilst controlling for one another as well as for demographic, disease-related and imaging variables.

Results: Higher fatigue correlated with lower sleep quality (r = 0.54, p < 0.0001). Higher fatigue was associated with lower FC of the precentral gyrus in the sensorimotor network, the precuneus in the posterior default-mode network and the superior frontal gyrus in the left fronto-parietal network, independently of sleep quality. Lower sleep quality was associated with lower FC of the left intraparietal sulcus in the left fronto-parietal network, independently of fatigue. Specific associations were found between fatigue and the sensorimotor network's global FC and between low sleep quality and the left fronto-parietal network's global FC.

Conclusion: Despite the high correlation between fatigue and low sleep quality in the clinical picture, our findings clearly indicate that, on the neural level, fatigue and low sleep quality in MS are associated with decreased FC in distinct functional brain networks.

Keywords: functional connectivity; left fronto-parietal network; multiple sclerosis; resting-state fMRI; sensorimotor network.

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References

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