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Comment
. 2022 Jun 14;15(738):eabq5594.
doi: 10.1126/scisignal.abq5594. Epub 2022 Jun 14.

Voltage-gated Ca2+ channel proteins do not function as ion channels in T cells

Michael D Cahalan  1   2
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Voltage-gated Ca2+ channel proteins do not function as ion channels in T cells

Michael D Cahalan. Sci Signal. .

Abstract

Calcium (Ca2+) signaling has long been known to be crucial for T cell activation. Erdogmus et al. tested the function of voltage-gated Ca2+ channel (CaV) proteins and discovered a nonchannel function mediated by an accessory subunit but found no evidence for CaV channel activity in T cells.

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