Bacterial Darth Vader: May the force be with you
- PMID: 35700706
- DOI: 10.1016/j.ccell.2022.05.008
Bacterial Darth Vader: May the force be with you
Abstract
The microbiome has a major impact on tumor progression, yet the mechanisms are poorly defined. Fu et al. report in Cell that intracellular bacteria in a breast cancer model promote metastasis via reorganizing the cytoskeleton to enhance resistance to mechanical stress, thereby facilitating survival in the circulation during dissemination.
Copyright © 2022 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests K.P. serves on the Scientific Advisory Board of Acrivon Therapeutics, Vividion Therapeutics, Scorpion Therapeutics, and Novartis Institute for BioMedical Research, holds equity options in Scorpion Therapeutics, is a consultant to Aria Pharmaceuticals, received honorarium from Astra-Zeneca and New Equilibrium Biosciences, and has an institutional research agreement with Novartis.
Comment on
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Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer.Cell. 2022 Apr 14;185(8):1356-1372.e26. doi: 10.1016/j.cell.2022.02.027. Epub 2022 Apr 7. Cell. 2022. PMID: 35395179
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