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Comment
. 2022 Jun 13;40(6):600-602.
doi: 10.1016/j.ccell.2022.05.008.

Bacterial Darth Vader: May the force be with you

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Bacterial Darth Vader: May the force be with you

Kornelia Polyak. Cancer Cell. .
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Abstract

The microbiome has a major impact on tumor progression, yet the mechanisms are poorly defined. Fu et al. report in Cell that intracellular bacteria in a breast cancer model promote metastasis via reorganizing the cytoskeleton to enhance resistance to mechanical stress, thereby facilitating survival in the circulation during dissemination.

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Conflict of interest statement

Declaration of interests K.P. serves on the Scientific Advisory Board of Acrivon Therapeutics, Vividion Therapeutics, Scorpion Therapeutics, and Novartis Institute for BioMedical Research, holds equity options in Scorpion Therapeutics, is a consultant to Aria Pharmaceuticals, received honorarium from Astra-Zeneca and New Equilibrium Biosciences, and has an institutional research agreement with Novartis.

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