Marijuana and endothelial dysfunction: new mechanism and therapy

Xiaojun Feng¹, Suowen Xu², Jianping Weng³

Affiliations

¹ Department of Endocrinology, Institute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, Clinical Research Hospital of Chinese Academy of Sciences (Hefei), University of Science and Technology of China, Hefei, Anhui, 230001, China.
² Department of Endocrinology, Institute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, Clinical Research Hospital of Chinese Academy of Sciences (Hefei), University of Science and Technology of China, Hefei, Anhui, 230001, China. Electronic address: sxu1984@ustc.edu.cn.
³ Department of Endocrinology, Institute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, Clinical Research Hospital of Chinese Academy of Sciences (Hefei), University of Science and Technology of China, Hefei, Anhui, 230001, China. Electronic address: wengjp@ustc.edu.cn.

PMID: 35701315
DOI: 10.1016/j.molmed.2022.05.009

Comment

Marijuana and endothelial dysfunction: new mechanism and therapy

Xiaojun Feng et al. Trends Mol Med. 2022 Aug.

. 2022 Aug;28(8):613-615.

doi: 10.1016/j.molmed.2022.05.009. Epub 2022 Jun 11.

Authors

Xiaojun Feng¹, Suowen Xu², Jianping Weng³

Affiliations

¹ Department of Endocrinology, Institute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, Clinical Research Hospital of Chinese Academy of Sciences (Hefei), University of Science and Technology of China, Hefei, Anhui, 230001, China.
² Department of Endocrinology, Institute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, Clinical Research Hospital of Chinese Academy of Sciences (Hefei), University of Science and Technology of China, Hefei, Anhui, 230001, China. Electronic address: sxu1984@ustc.edu.cn.
³ Department of Endocrinology, Institute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, Clinical Research Hospital of Chinese Academy of Sciences (Hefei), University of Science and Technology of China, Hefei, Anhui, 230001, China. Electronic address: wengjp@ustc.edu.cn.

PMID: 35701315
DOI: 10.1016/j.molmed.2022.05.009

Abstract

Marijuana (cannabis) can cause cardiovascular side effects, yet the mechanisms and treatments remain poorly understood. In a recent study published in Cell, Wei et al. discovered that soy isoflavone genistein attenuates Δ9-tetrahydrocannabinol (Δ9-THC, a main constituent from marijuana)-induced endothelial dysfunction and atherosclerosis by directly antagonizing peripheral cannabinoid receptor 1, demonstrating a therapeutic potential for ameliorating the cardiovascular side effects of cannabis.

Keywords: atherosclerosis; endothelial dysfunction; genistein; inflammation; marijuana; oxidative stress.

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Conflict of interest statement

Declaration of interests The authors have no conflicts of interest to disclose.

Comment on

Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation.
Wei TT, Chandy M, Nishiga M, Zhang A, Kumar KK, Thomas D, Manhas A, Rhee S, Justesen JM, Chen IY, Wo HT, Khanamiri S, Yang JY, Seidl FJ, Burns NZ, Liu C, Sayed N, Shie JJ, Yeh CF, Yang KC, Lau E, Lynch KL, Rivas M, Kobilka BK, Wu JC. Wei TT, et al. Cell. 2022 May 12;185(10):1676-1693.e23. doi: 10.1016/j.cell.2022.04.005. Epub 2022 Apr 29. Cell. 2022. PMID: 35489334 Free PMC article.

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Marijuana and endothelial dysfunction: new mechanism and therapy

Affiliations

Marijuana and endothelial dysfunction: new mechanism and therapy

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Affiliations

Abstract

Conflict of interest statement

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