Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 May 9;14(5):e24847.
doi: 10.7759/cureus.24847. eCollection 2022 May.

Studying the Relation Between Fibromyalgia Severity and Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Mean Platelet Volume

Acchudha Krishnan Rajaram Jayakrishnan  1 , Sekhar V Easwar  1 , Joslyn Thattil  1 , Mani Vignesh  1 , Sudeep Rath  1 , Abhinav Prithvi  1 , Vishal Marwaha  1 , Mithun Cb  1 , Sandeep Surendran  1
Affiliations

Studying the Relation Between Fibromyalgia Severity and Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Mean Platelet Volume

Acchudha Krishnan Rajaram Jayakrishnan et al. Cureus. .

Abstract

Background: Fibromyalgia is characterized by chronic widespread pain, which has been linked to neuroinflammation. Hematological indices, i.e., neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) have been shown to be effective markers in neurological diseases like depression.

Aims: To study the association between fibromyalgia severity and the hematological indices (NLR, PLR, and MPV).

Subjects and methods: This was a hospital-based cross-sectional study of fibromyalgia patients satisfying the 2016 modification of the 2010/11 ACR criteria. Demographic and clinical characteristics were recorded along with fibromyalgia outcomes and hematological indices. Statistical analysis was done using descriptive statistics, ROC analysis using the Youden index, and Pearson and Spearman correlations.

Results: A total of 266 patients were recruited. The (mean ± S.D) NLR, MPV, and PLR were 1.92 ± 1.26, 8.94 ± 1.25, and 119.48 ± 76.91, respectively. Patients with severe visual analog scale (VAS) pain scores had lower MPV (8.8 ± 1.3) than those with mild/moderate pain (9.2 ± 1.1, p = 0.016). MPV showed a mild negative correlation with the Fibromyalgia Impact Questionnaire-Revised (FIQR) score (R2 -0.31 p 0.004). MPV threshold of 8.95 was discriminated severely from mild/moderate VAS-pain score with a sensitivity of 52.3 % and specificity of 66.7%.

Conclusions: MPV can possibly be considered as a biomarker for predicting pain severity in fibromyalgia. Given its inexpensive nature, MPV can be used as a cost-effective method to assess fibromyalgia severity in rural India.

Keywords: fibromyalgia; mean platelet volume; neuroinflammation; neutrophil to lymphocyte ratio (nlr); visual analogue scale.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Scatter Plot Showing the Relation Between MPV and FIQR Scores
MPV: mean platelet volume; FIQR: Fibromyalgia Impact Questionnaire-Revised
See this image and copyright information in PMC

References

    1. The prevalence and characteristics of fibromyalgia in the general population. Wolfe F, Ross K, Anderson J, Russell IJ, Hebert L. Arthritis Rheum. 1995;38:19–28. - PubMed
    1. Fibromyalgia syndrome and small fiber, early or mild sensory polyneuropathy. Lawson VH, Grewal J, Hackshaw KV, Mongiovi PC, Stino AM. Muscle Nerve. 2018;58:625–630. - PMC - PubMed
    1. Neurogenic inflammation in fibromyalgia. Littlejohn G, Guymer E. Semin Immunopathol. 2018;40:291–300. - PubMed
    1. Systematic review with meta-analysis: cytokines in fibromyalgia syndrome. Uçeyler N, Häuser W, Sommer C. BMC Musculoskelet Disord. 2011;12:245. - PMC - PubMed
    1. Cytokine patterns in fibromyalgia and their correlation with clinical manifestations. Bazzichi L, Rossi A, Massimetti G, et al. https://www.clinexprheumatol.org/abstract.asp?a=3055. Clin Exp Rheumatol. 2007;25:225–230. - PubMed

LinkOut - more resources