Outcome of infection with omicron SARS-CoV-2 variant in patients with hematological malignancies: An EPICOVIDEHA survey report

Ola Blennow¹, Jon Salmanton-García^{2

3}, Piotr Nowak¹, Federico Itri⁴, Jaap Van Doesum⁵, Alberto López-García⁶, Francesca Farina⁷, Ozren Jaksic⁸, László Imre Pinczés⁹, Yavuz M Bilgin¹⁰, Iker Falces-Romero^{11

12}, Moraima Jiménez^{13

14}, Irati Ormazabal-Vélez¹⁵, Barbora Weinbergerová¹⁶, Rémy Duléry¹⁷, Zlate Stojanoski¹⁸, Tobias Lahmer¹⁹, Noemí Fernández²⁰, José-Ángel Hernández-Rivas²¹, Verena Petzer²², Nick De Jonge²³, Andreas Glenthøj²⁴, Cristina De Ramón^{25

26}, Monika M Biernat²⁷, Nicola Fracchiolla²⁸, Avinash Aujayeb²⁹, Jens Van Praet³⁰, Martin Schönlein³¹, Gustavo-Adolfo Méndez³², Chiara Cattaneo³³, Anna Guidetti³⁴, Mariarita Sciumè²⁸, Emanuele Ammatuna⁵, Raul Cordoba⁶, Nicole García-Poutón³⁵, Stefanie Gräfe^{2

3

36}, Alba Cabirta^{13

14}, Dominik Wolf²², Anna Nordlander¹, Ramón García-Sanz^{25

26}, Mario Delia³⁷, Caroline Berg Venemyr²⁴, Clara Brones³⁸, Roberta Di Blasi³⁹, Elizabeth De Kort⁴⁰, Stef Meers⁴¹, Sylvain Lamure⁴², Laura Serrano⁴³, Maria Merelli⁴⁴, Nicola Coppola⁴⁵, Rui Bergantim⁴⁶, Caroline Besson³⁸, Milena Kohn³⁸, Jessica Petiti⁴⁷, Carolina Garcia-Vidal³⁵, Michelina Dargenio⁴⁸, François Danion⁴⁹, Marina Machado⁵⁰, Rebeca Bailén-Almorox⁵¹, Martin Hoenigl^{52

53

54}, Giulia Dragonetti⁵⁵, Louis Yi Ann Chai⁵⁶, Chi Shan Kho⁵⁷, Matteo Bonanni^{55

58}, Raphaël Liévin³⁹, Francesco Marchesi⁵⁹, Oliver A Cornely^{2

3

60

61

62}, Livio Pagano^{55

58}

Affiliations

¹ Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.
² Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), University of Cologne, Cologne, Germany.
³ Faculty of Medicine and University Hospital Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
⁴ Department of Clinical and Biological Sciences, San Luigi Gonzaga Hospital - Orbassano, Orbassano, Italy.
⁵ Department of Hematology, University Medical Center Groningen, Groningen, The Netherlands.
⁶ Health Research Institute IIS-FJD, Fundacion Jimenez Diaz University Hospital, Madrid, Spain.
⁷ U.O. Ematologia e Trapianto Midollo, Dipartimento di Oncologia Istituto Scientifico San Raffaele, Milan, Italy.
⁸ Department of Hematology, University Hospital Dubrava, Zagreb, Croatia.
⁹ Division of Hematology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
¹⁰ Department of Internal Medicine/Hematology, ADRZ, Goes, Netherlands.
¹¹ Microbiology and Parasitology Department, University Hospital La Paz, Madrid, Spain.
¹² CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain.
¹³ Department of Hematology, Vall d'Hebron Hospital Universitari, Experimental Hematology, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
¹⁴ Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain.
¹⁵ Department of Haematology, Complejo Hospitalario de Navarra, Pamplona, Spain.
¹⁶ Department of Internal Medicine, Hematology and Oncology, Masaryk University and University Hospital Brno, Brno, Czech Republic.
¹⁷ INSERM UMRs 938, Service d'Hématologie Clinique et de Thérapie Cellulaire, Hôpital Saint Antoine, AP-HP, Sorbonne Université, Paris, France.
¹⁸ University Clinic for Hematology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje, North Macedonia.
¹⁹ Medizinische Klinik II, Klinikum rechts der Isar, TU München, Munich, Germany.
²⁰ Department of Hematology, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
²¹ Deparment of Hematology, Hospital Universitario Infanta Leonor, Madrid, Spain.
²² Department of Hematology and Oncology, Medical University of Innsbruck, Innsbruck, Austria.
²³ Department of Hematology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
²⁴ Department of Hematology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
²⁵ Hematology Department, Hospital Universitario de Salamanca, Salamanca, Spain.
²⁶ Centro de Investigación del Cáncer-IBMCC (USAL-CSIC), IBSAL, Salamanca, Spain.
²⁷ Department of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw, Poland.
²⁸ Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
²⁹ Respiratory Department, Northumbria Healthcare, Newcastle, UK.
³⁰ Department of Nephrology and Infectious diseases, AZ Sint-Jan Brugge-Oostende AV, Brugge, Belgium.
³¹ Department of Oncology, Hematology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
³² Servicio de Infectología y Control de Infecciones, Hospital Escuela de Agudos Dr. Ramón Madariaga, Posadas, Misiones, Argentina.
³³ Hematology Unit, ASST-Spedali Civili, Brescia, Italy.
³⁴ Division of Hematology and Bone Marrow Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
³⁵ Department of Infectious Diseases, Hospital Clinic de Barcelona, University of Barcelona, IDIBAPS, Barcelona, Spain.
³⁶ Department of Oncology, Hematology, and Bone Marrow Transplantation with Section of Pneumology, Universitätsklinikum Hamburg Eppendorf, Hamburg, Germany.
³⁷ Hematology and Stem Cell Transplantation Unit, AOUC Policlinico, Bari, Italy.
³⁸ Service d'Hématologie, Centre Hospitalier de Versailles, Le Chesnay, France.
³⁹ Hemato-Oncology Department, Hopital Saint Louis, Paris, France.
⁴⁰ Department of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands.
⁴¹ Department Oncology, AZ KLINA, Brasschaat, Belgium.
⁴² Department of Clinical Hematology, Montpellier University Hospital, IGMM UMR5535 CNRS, University of Montpellier, Montpellier, France.
⁴³ Deparment of Hematology, Hospital Universitario de Cabueñes, Gijón, Spain.
⁴⁴ Infectious Diseas Clinic, ASU FC Udine Hospital, Udine, Italy.
⁴⁵ Department of Mental Health and Public Medicine, Universitry of Campania, Naples, Italy.
⁴⁶ Department of Hematology, Centro Hospitalar e Universitário de São João, Porto, Portugal.
⁴⁷ Department of Clinical and Biological Sciences, University of Turin, Turin, Italy.
⁴⁸ Hematology and Stem Cell Transplant Unit, "Vito Fazzi" Hospital, Lecce, Italy.
⁴⁹ Department of Infectious Diseases, CHU de Strasbourg, Strasbourg, France.
⁵⁰ Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
⁵¹ Department of Hematology and Hemotherapy, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
⁵² Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, San Diego, California, USA.
⁵³ Clinical and Translational Fungal-Working Group, University of California San Diego, La Jolla, California, USA.
⁵⁴ Division of Infectious Diseases, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
⁵⁵ Hematology Unit, Fondazione Policlinico Universitario Agostino Gemelli - IRCCS, Rome, Italy.
⁵⁶ National University Health System, University Medicine Center, Division of Infectious Diseases, Singapore.
⁵⁷ Pamela Youde Nethersole Eastern Hospital, Hong Kong, Hong Kong SAR.
⁵⁸ Hematology Unit, Università Cattolica del Sacro Cuore, Rome, Italy.
⁵⁹ Hematology and Stem Cell Transplant Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
⁶⁰ Faculty of Medicine and University Hospital Cologne, Clinical Trials Centre Cologne (ZKS Köln), University of Cologne, Cologne, Germany.
⁶¹ Faculty of Medicine and University Hospital Cologne, Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
⁶² German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.

PMID: 35702878
PMCID: PMC9349555
DOI: 10.1002/ajh.26626

Outcome of infection with omicron SARS-CoV-2 variant in patients with hematological malignancies: An EPICOVIDEHA survey report

Ola Blennow et al. Am J Hematol. 2022 Aug.

. 2022 Aug;97(8):E312-E317.

doi: 10.1002/ajh.26626. Epub 2022 Jun 28.

Authors

Affiliations

¹ Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.
² Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), University of Cologne, Cologne, Germany.
³ Faculty of Medicine and University Hospital Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
⁴ Department of Clinical and Biological Sciences, San Luigi Gonzaga Hospital - Orbassano, Orbassano, Italy.
⁵ Department of Hematology, University Medical Center Groningen, Groningen, The Netherlands.
⁶ Health Research Institute IIS-FJD, Fundacion Jimenez Diaz University Hospital, Madrid, Spain.
⁷ U.O. Ematologia e Trapianto Midollo, Dipartimento di Oncologia Istituto Scientifico San Raffaele, Milan, Italy.
⁸ Department of Hematology, University Hospital Dubrava, Zagreb, Croatia.
⁹ Division of Hematology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
¹⁰ Department of Internal Medicine/Hematology, ADRZ, Goes, Netherlands.
¹¹ Microbiology and Parasitology Department, University Hospital La Paz, Madrid, Spain.
¹² CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain.
¹³ Department of Hematology, Vall d'Hebron Hospital Universitari, Experimental Hematology, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
¹⁴ Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain.
¹⁵ Department of Haematology, Complejo Hospitalario de Navarra, Pamplona, Spain.
¹⁶ Department of Internal Medicine, Hematology and Oncology, Masaryk University and University Hospital Brno, Brno, Czech Republic.
¹⁷ INSERM UMRs 938, Service d'Hématologie Clinique et de Thérapie Cellulaire, Hôpital Saint Antoine, AP-HP, Sorbonne Université, Paris, France.
¹⁸ University Clinic for Hematology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje, North Macedonia.
¹⁹ Medizinische Klinik II, Klinikum rechts der Isar, TU München, Munich, Germany.
²⁰ Department of Hematology, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
²¹ Deparment of Hematology, Hospital Universitario Infanta Leonor, Madrid, Spain.
²² Department of Hematology and Oncology, Medical University of Innsbruck, Innsbruck, Austria.
²³ Department of Hematology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
²⁴ Department of Hematology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
²⁵ Hematology Department, Hospital Universitario de Salamanca, Salamanca, Spain.
²⁶ Centro de Investigación del Cáncer-IBMCC (USAL-CSIC), IBSAL, Salamanca, Spain.
²⁷ Department of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw, Poland.
²⁸ Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
²⁹ Respiratory Department, Northumbria Healthcare, Newcastle, UK.
³⁰ Department of Nephrology and Infectious diseases, AZ Sint-Jan Brugge-Oostende AV, Brugge, Belgium.
³¹ Department of Oncology, Hematology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
³² Servicio de Infectología y Control de Infecciones, Hospital Escuela de Agudos Dr. Ramón Madariaga, Posadas, Misiones, Argentina.
³³ Hematology Unit, ASST-Spedali Civili, Brescia, Italy.
³⁴ Division of Hematology and Bone Marrow Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
³⁵ Department of Infectious Diseases, Hospital Clinic de Barcelona, University of Barcelona, IDIBAPS, Barcelona, Spain.
³⁶ Department of Oncology, Hematology, and Bone Marrow Transplantation with Section of Pneumology, Universitätsklinikum Hamburg Eppendorf, Hamburg, Germany.
³⁷ Hematology and Stem Cell Transplantation Unit, AOUC Policlinico, Bari, Italy.
³⁸ Service d'Hématologie, Centre Hospitalier de Versailles, Le Chesnay, France.
³⁹ Hemato-Oncology Department, Hopital Saint Louis, Paris, France.
⁴⁰ Department of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands.
⁴¹ Department Oncology, AZ KLINA, Brasschaat, Belgium.
⁴² Department of Clinical Hematology, Montpellier University Hospital, IGMM UMR5535 CNRS, University of Montpellier, Montpellier, France.
⁴³ Deparment of Hematology, Hospital Universitario de Cabueñes, Gijón, Spain.
⁴⁴ Infectious Diseas Clinic, ASU FC Udine Hospital, Udine, Italy.
⁴⁵ Department of Mental Health and Public Medicine, Universitry of Campania, Naples, Italy.
⁴⁶ Department of Hematology, Centro Hospitalar e Universitário de São João, Porto, Portugal.
⁴⁷ Department of Clinical and Biological Sciences, University of Turin, Turin, Italy.
⁴⁸ Hematology and Stem Cell Transplant Unit, "Vito Fazzi" Hospital, Lecce, Italy.
⁴⁹ Department of Infectious Diseases, CHU de Strasbourg, Strasbourg, France.
⁵⁰ Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
⁵¹ Department of Hematology and Hemotherapy, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
⁵² Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, San Diego, California, USA.
⁵³ Clinical and Translational Fungal-Working Group, University of California San Diego, La Jolla, California, USA.
⁵⁴ Division of Infectious Diseases, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
⁵⁵ Hematology Unit, Fondazione Policlinico Universitario Agostino Gemelli - IRCCS, Rome, Italy.
⁵⁶ National University Health System, University Medicine Center, Division of Infectious Diseases, Singapore.
⁵⁷ Pamela Youde Nethersole Eastern Hospital, Hong Kong, Hong Kong SAR.
⁵⁸ Hematology Unit, Università Cattolica del Sacro Cuore, Rome, Italy.
⁵⁹ Hematology and Stem Cell Transplant Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
⁶⁰ Faculty of Medicine and University Hospital Cologne, Clinical Trials Centre Cologne (ZKS Köln), University of Cologne, Cologne, Germany.
⁶¹ Faculty of Medicine and University Hospital Cologne, Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
⁶² German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.

PMID: 35702878
PMCID: PMC9349555
DOI: 10.1002/ajh.26626

No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests for this work.

References

1. Pagano L, Salmanton‐Garcia J, Marchesi F, et al. COVID‐19 infection in adult patients with hematological malignancies: a European Hematology Association survey (EPICOVIDEHA). J Hematol Oncol. 2021;14(1):168. - PMC - PubMed
1. Bruel T, Hadjadj J, Maes P, et al. Serum neutralization of SARS‐CoV‐2 omicron sublineages BA.1 and BA.2 in patients receiving monoclonal antibodies. Nat Med. 2022;28(6):1297‐1302. - PubMed
1. Nyberg T, Ferguson NM, Nash SG, et al. Comparative analysis of the risks of hospitalisation and death associated with SARS‐CoV‐2 omicron (B.1.1.529) and delta (B.1.617.2) variants in England: a cohort study. Lancet. 2022;399(10332):1303‐1312. - PMC - PubMed
1. Christensen PA, Olsen RJ, Long SW, et al. Signals of significantly increased vaccine breakthrough, decreased hospitalization rates, and less severe disease in patients with coronavirus disease 2019 caused by the omicron variant of severe acute respiratory syndrome coronavirus 2 in Houston, Texas. Am J Pathol. 2022;192(4):642‐652. - PMC - PubMed
1. Tseng HF, Ackerson BK, Luo Y, et al. Effectiveness of mRNA‐1273 against SARS‐CoV‐2 omicron and Delta variants. Nat Med. 2022;28(5):1063‐1071. - PMC - PubMed

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Outcome of infection with omicron SARS-CoV-2 variant in patients with hematological malignancies: An EPICOVIDEHA survey report

Affiliations

Outcome of infection with omicron SARS-CoV-2 variant in patients with hematological malignancies: An EPICOVIDEHA survey report

Authors

Affiliations

Conflict of interest statement

References

Publication types

MeSH terms

Supplementary concepts

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous