Longitudinal Retinal Changes in MOGAD

Frederike Cosima Oertel^#^{1

2

3}, Elias S Sotirchos^#⁴, Hanna G Zimmermann^{1

2}, Seyedamirhosein Motamedi^{1

2}, Svenja Specovius^{1

2}, Eva Susanna Asseyer^{1

2}, Claudia Chien^{1

2}, Lawrence Cook⁵, Eleni Vasileiou⁴, Angeliki Filippatou⁴, Peter A Calabresi⁴, Shiv Saidha⁴, Lekha Pandit⁶, Anitha D'Cunha⁶, Olivier Outteryck⁷, Hélène Zéphir⁷, Sean Pittock⁸, Eoin P Flanagan⁸, M Tariq Bhatti⁸, Paulus S Rommer⁹, Gabriel Bsteh⁹, Tobias Zrzavy⁹, Tania Kuempfel¹⁰, Orhan Aktas¹¹, Marius Ringelstein^{11

12}, Philipp Albrecht¹¹, Ilya Ayzenberg^{13

14}, Thivya Pakeerathan^{13

14}, Benjamin Knier¹⁵, Lilian Aly¹⁵, Nasrin Asgari¹⁶, Kerstin Soelberg¹⁷, Romain Marignier¹⁸, Caroline Froment Tilikete¹⁸, Alvaro Cobo Calvo^{18

19}, Pablo Villoslada²⁰, Bernardo Sanchez-Dalmau²⁰, Elena H Martinez-Lapiscina²⁰, Sara Llufriu²⁰, Ari J Green³, Michael R Yeaman^{21

22}, Terry J Smith^{23

24}, Alexander U Brandt^{1

2

25}, John Chen^#^{8

26}, Friedemann Paul^#^{1

2

27}, Joachim Havla^#^{10

28}; with the GJCF International Clinical Consortium for NMOSD and the CROCTINO study group

Collaborators, Affiliations

Collaborators

with the GJCF International Clinical Consortium for NMOSD and the CROCTINO study group:
Ayse Altintas, Fereshte Ashtari, Denis Bichuetti, Ibis Soto de Castillo, Mariana Andrade, Fontenelle, Saif Huda, Jae-Won Hyun, Anu Jacob, Rahele Kafieh, Ho Jin Kim, Letizia Leocani, Yang Mao-Draayer, Marie Isabel Leite, Eugene F May, Jaqueline Palace, Marco Aurélio Lana Peixoto, Marco Pisa, Marta Radaelli, Zoe Rimler, Adriana Roca-Fernandez, Thomas Senger, Jérôme de Seze, Sasitorn Siritho, Hadas Stiebel-Kalish, Uygur Tanriverdi, Ivan Maynart Tavares, Caryl Tongco

Affiliations

¹ Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universitätzu Berlin, Berlin, Germany.
² NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
³ Department of Neurology, University of California San Francisco, San Francisco, CA.
⁴ Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD.
⁵ Department of Pediatrics, University of Utah, Salt Lake City, UT.
⁶ Department of Neurology, KS Hegde Medical Academy, Nitte University, Mangalore, India.
⁷ Department of Neuroradiology, CHU Lille, Université de Lille, Lille, Hauts-de-France, France.
⁸ Department of Neurology, Mayo Clinic, Rochester, MN.
⁹ Department of Neurology, Medical University of Vienna, Vienna, Austria.
¹⁰ Institute of Clinical Neuroimmunology, Biomedical Center and University Hospital, Ludwig-Maximilians Universität München, Munich, Germany.
¹¹ Department of Neurology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
¹² Department of Neurology, Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
¹³ Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.
¹⁴ Department of Neurology, I.M. Sechenov First Department of Neurology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
¹⁵ Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.
¹⁶ Departments of Neurology, Lillebaelt & Slagelse Hospitals, Denmark.
¹⁷ Institute of Regional Health Research and of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
¹⁸ Departments of Neurology, Multiple Sclerosis, Myelin Disorders, and Neuroinflammation, Pierre Wertheimer Neurological Hospital, Hospices Civils de Lyon, Lyon, France.
¹⁹ Centre d'Esclerosi Múltiple de Catalunya (Cemcat). Department of Neurology/Neuroimmunology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
²⁰ Hospital Clinic of Barcelona-Institut d'Investigacions, Biomèdiques August Pi Sunyer, (IDIBAPS), Barcelona, Spain.
²¹ Division of Molecular Medicine, Harbor - University of California at Los Angeles (UCLA) Medical Center, Torrance, CA.
²² Department of Medicine, David Geffen School of Medicine at University of California at Los Angeles (UCLA), Los Angeles.Los Angeles, CA.
²³ Departments of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, MI.
²⁴ Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI.
²⁵ Department of Neurology, University of California, Irvine, CA.
²⁶ Department of Ophthalmology, Mayo Clinic, Rochester, MN.
²⁷ Department of Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
²⁸ Data Integration for Future Medicine (DIFUTURE) Consortium, LMU Hospital, Ludwig-Maximilians Universität München, Munich, Germany.

^# Contributed equally.

PMID: 35703428
DOI: 10.1002/ana.26440

Free article

Longitudinal Retinal Changes in MOGAD

Frederike Cosima Oertel et al. Ann Neurol. 2022 Sep.

Free article

. 2022 Sep;92(3):476-485.

doi: 10.1002/ana.26440. Epub 2022 Jul 16.

Authors

Collaborators

with the GJCF International Clinical Consortium for NMOSD and the CROCTINO study group:
Ayse Altintas, Fereshte Ashtari, Denis Bichuetti, Ibis Soto de Castillo, Mariana Andrade, Fontenelle, Saif Huda, Jae-Won Hyun, Anu Jacob, Rahele Kafieh, Ho Jin Kim, Letizia Leocani, Yang Mao-Draayer, Marie Isabel Leite, Eugene F May, Jaqueline Palace, Marco Aurélio Lana Peixoto, Marco Pisa, Marta Radaelli, Zoe Rimler, Adriana Roca-Fernandez, Thomas Senger, Jérôme de Seze, Sasitorn Siritho, Hadas Stiebel-Kalish, Uygur Tanriverdi, Ivan Maynart Tavares, Caryl Tongco

Affiliations

¹ Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universitätzu Berlin, Berlin, Germany.
² NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
³ Department of Neurology, University of California San Francisco, San Francisco, CA.
⁴ Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD.
⁵ Department of Pediatrics, University of Utah, Salt Lake City, UT.
⁶ Department of Neurology, KS Hegde Medical Academy, Nitte University, Mangalore, India.
⁷ Department of Neuroradiology, CHU Lille, Université de Lille, Lille, Hauts-de-France, France.
⁸ Department of Neurology, Mayo Clinic, Rochester, MN.
⁹ Department of Neurology, Medical University of Vienna, Vienna, Austria.
¹⁰ Institute of Clinical Neuroimmunology, Biomedical Center and University Hospital, Ludwig-Maximilians Universität München, Munich, Germany.
¹¹ Department of Neurology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
¹² Department of Neurology, Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
¹³ Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.
¹⁴ Department of Neurology, I.M. Sechenov First Department of Neurology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
¹⁵ Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.
¹⁶ Departments of Neurology, Lillebaelt & Slagelse Hospitals, Denmark.
¹⁷ Institute of Regional Health Research and of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
¹⁸ Departments of Neurology, Multiple Sclerosis, Myelin Disorders, and Neuroinflammation, Pierre Wertheimer Neurological Hospital, Hospices Civils de Lyon, Lyon, France.
¹⁹ Centre d'Esclerosi Múltiple de Catalunya (Cemcat). Department of Neurology/Neuroimmunology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
²⁰ Hospital Clinic of Barcelona-Institut d'Investigacions, Biomèdiques August Pi Sunyer, (IDIBAPS), Barcelona, Spain.
²¹ Division of Molecular Medicine, Harbor - University of California at Los Angeles (UCLA) Medical Center, Torrance, CA.
²² Department of Medicine, David Geffen School of Medicine at University of California at Los Angeles (UCLA), Los Angeles.Los Angeles, CA.
²³ Departments of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, MI.
²⁴ Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI.
²⁵ Department of Neurology, University of California, Irvine, CA.
²⁶ Department of Ophthalmology, Mayo Clinic, Rochester, MN.
²⁷ Department of Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
²⁸ Data Integration for Future Medicine (DIFUTURE) Consortium, LMU Hospital, Ludwig-Maximilians Universität München, Munich, Germany.

^# Contributed equally.

PMID: 35703428
DOI: 10.1002/ana.26440

Abstract

Objective: Patients with myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-associated disease (MOGAD) suffer from severe optic neuritis (ON) leading to retinal neuro-axonal loss, which can be quantified by optical coherence tomography (OCT). We assessed whether ON-independent retinal atrophy can be detected in MOGAD.

Methods: Eighty patients with MOGAD and 139 healthy controls (HCs) were included. OCT data was acquired with (1) Spectralis spectral domain OCT (MOGAD: N = 66 and HCs: N = 103) and (2) Cirrus high-definition OCT (MOGAD: N = 14 and HCs: N = 36). Macular combined ganglion cell and inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) were quantified.

Results: At baseline, GCIPL and pRNFL were lower in MOGAD eyes with a history of ON (MOGAD-ON) compared with MOGAD eyes without a history of ON (MOGAD-NON) and HCs (p < 0.001). MOGAD-NON eyes had lower GCIPL volume compared to HCs (p < 0.001) in the Spectralis, but not in the Cirrus cohort. Longitudinally (follow-up up to 3 years), MOGAD-ON with ON within the last 6-12 months before baseline exhibited greater pRNFL thinning than MOGAD-ON with an ON greater than 12 months ago (p < 0.001). The overall MOGAD cohort did not exhibit faster GCIPL thinning compared with the HC cohort.

Interpretation: Our study suggests the absence of attack-independent retinal damage in patients with MOGAD. Yet, ongoing neuroaxonal damage or edema resolution seems to occur for up to 12 months after ON, which is longer than what has been reported with other ON forms. These findings support that the pathomechanisms underlying optic nerve involvement and the evolution of OCT retinal changes after ON is distinct in patients with MOGAD. ANN NEUROL 2022;92:476-485.

PubMed Disclaimer

References

1. Schmidt F, Zimmermann H, Mikolajczak J, et al. Severe structural and functional visual system damage leads to profound loss of vision-related quality of life in patients with neuromyelitis optica spectrum disorders. Mult Scler Relat Disord 2017;11:45-50.
1. Oertel FC, Outteryck O, Knier B, et al. Optical coherence tomography in myelin-oligodendrocyte-glycoprotein antibody-seropositive patients: a longitudinal study. J Neuroinflammation 2019;16:154.
1. Filippatou AG, Mukharesh L, Saidha S, et al. AQP4-IgG and MOG-IgG related optic neuritis-prevalence, optical coherence tomography findings, and visual outcomes: a systematic review and meta-analysis. Front Neurol 2020;11:540156.
1. Sotirchos ES, Filippatou A, Fitzgerald KC, et al. Aquaporin-4 IgG seropositivity is associated with worse visual outcomes after optic neuritis than MOG-IgG seropositivity and multiple sclerosis, independent of macular ganglion cell layer thinning. Mult Scler 2019;1352458519864928:1360-1371.
1. Spadaro M, Gerdes LA, Mayer MC, et al. Histopathology and clinical course of MOG-antibody-associated encephalomyelitis. Ann Clin Transl Neurol 2015;2:295-301.

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
Miscellaneous
- NCI CPTAC Assay Portal

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Longitudinal Retinal Changes in MOGAD

Collaborators

Affiliations

Longitudinal Retinal Changes in MOGAD

Authors

Collaborators

Affiliations

Abstract

References

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Miscellaneous