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Review
. 2022 Aug 1;38(8):536-540.
doi: 10.1097/AJP.0000000000001045.

Phenotypes and Genotypes in Postherpetic Neuralgia Drug Therapy: A Narrative Mini-review

Udochukwu G Anosike  1 , Innocent Ouko  2 , Anita W Mwaura  2 , Ibsen Ongidi  2 , Chijioke C Mbonu  1
Affiliations
Review

Phenotypes and Genotypes in Postherpetic Neuralgia Drug Therapy: A Narrative Mini-review

Udochukwu G Anosike et al. Clin J Pain. .

Abstract

Neuropathic pain is a debilitating symptom reported by patients presenting with postherpetic neuralgia (PHN). Efforts to alleviate this pain have been projected to lie in individualization of pharmacological treatment through pain phenotyping and subsequent investigations into the genetic basis of PHN therapy. Understanding the various mechanisms related to these phenotypes can aid in improvement of available treatment options and discovery of new ones. Knowledge and application of genetic variations in PHN, structural proteins, and genes can aid in ascertaining risk, susceptibility to, severity of, and protection from PHN. This review summarizes the most recent information that has been published on phenotypes and genotypes with possible clinical applications and directions for future research.

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Conflict of interest statement

The authors declare no conflict of interest.

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