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. 2022 Jun;54(2):186-190.
doi: 10.5152/eurasianjmed.2022.21293.

High Fetuin-A Levels in Children with Celiac Disease

Nezahat Kurt  1 , Fatma Betul Ozgeris  2 , Burcu Volkan  3 , Mehmet Ali Gul  4 , Atilla Cayir  5
Affiliations

High Fetuin-A Levels in Children with Celiac Disease

Nezahat Kurt et al. Eurasian J Med. 2022 Jun.

Abstract

Objective: Fetuin-A is a multifunctional non-collagen protein that plays a role in bone mineralization. Celiac disease is a chronic inflammatory disorder of the small intestine due to exposure to gluten. In this research, it was aimed to investigate levels of Fetuin-A and its relationship with bone mineral density in children with celiac disease.

Materials and methods: The study was conducted on 59 children with celiac and 29 healthy children. The celiac disease group was composed of three groups, newly diagnosed, gluten-free diet compliant and, non- gluten- free diet compliant patients. Serum Fetuin-A concentrations were measured by an enzyme-linked immuno- sorbent assay kit. Measurement of bone mineral density was performed a dual-energy x-ray absorptiometry.

Results: Serum Fetuin-A levels were 136.85 ± 38.09 μg/L and 112.95 ± 44.39 μg/L in the celiac disease and healthy control groups, respectively. There was a statistically significant difference between groups in levels of serum Fetuin-A (P < .05). A significant positive correlation was observed between serum Fetuin-A and bone mineral density Z-score in the celiac patients.

Conclusion: Increased Fetuin-A levels and positive correlation between Fetuin-A and bone mineral density in children with celiac disease suggest that Fetuin-A may be a biomarker for celiac disease.

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Figures

Figure 1.
Figure 1.
Serum Fetuin-A levels in patient and healthy control group (A), Serum Fetuin-A levels in celiac subgroups (B).
Figure 2.
Figure 2.
Correlation between Fetuin-A level and BMD Z-score in patient (r = 0.257, P < .05).
See this image and copyright information in PMC

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