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Review
. 2022 Jun 10;118(6):1134-1140.
doi: 10.36660/abc.20201383. eCollection 2022.

LncRNAs are Involved in the Process of Atherosclerosis at Diverse Levels

[Article in English, Portuguese]
Shiyi Liang  1 , Weicheng Xv  1 , Chijian Li  1 , Yuxiang Huang  1 , Ge Qian  1 , Yuxiang Yan  2 , Hequn Zou  3 , Yongqiang Li  4
Affiliations
Review

LncRNAs are Involved in the Process of Atherosclerosis at Diverse Levels

[Article in English, Portuguese]
Shiyi Liang et al. Arq Bras Cardiol. .

Abstract
in English, Portuguese

Atherosclerosis is the most common cause of cardiovascular disease globally, associated with a high incidence of clinical events. Accumulating evidence has elucidated that long non-coding RNAs (lncRNAs) as a novel class of transcripts with critical roles in the pathophysiological processes of atherosclerosis. In this review, we summarize the recent progress of lncRNAs in the development of atherosclerosis. We mainly describe the diverse regulatory mechanisms of lncRNAs at the transcriptional and post-transcriptional levels. This study may provide helpful insights about lncRNAs as therapeutic targets or biomarkers for atherosclerosis treatment.

A aterosclerose é a causa mais comum de doença cardiovascular em todo o mundo, ela está associada a uma alta incidência de eventos clínicos. O acúmulo de evidências elucidou que os RNAs longos não codificantes (LncRNAs) são uma nova classe de transcritos com papéis críticos nos processos fisiopatológicos da aterosclerose. Nesta revisão, resumimos o progresso recente dos LncRNAs no desenvolvimento da aterosclerose. Descrevemos principalmente os diversos mecanismos regulatórios dos LncRNAs nos níveis transcricionais e pós-transcricionais. Este estudo pode fornecer informações úteis sobre os LncRNAs como alvos terapêuticos ou biomarcadores para o tratamento da aterosclerose.

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Conflict of interest statement

Potencial conflito de interesse

Não há conflito com o presente artigo

Figures

Figura 1
Figura 1. A patogênese da aterosclerose.
Figure 1
Figure 1. The pathogenesis of atherosclerosis.
See this image and copyright information in PMC

References

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