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Review
. 2022 Dec;102(15):6795-6803.
doi: 10.1002/jsfa.12074. Epub 2022 Jun 30.

Dietary fiber ameliorates lead-induced gut microbiota disturbance and alleviates neuroinflammation

Mei Yao  1 , Xingfeng Shao  1 , Yingying Wei  1 , Xin Zhang  1 , Hongfei Wang  1 , Feng Xu  1
Affiliations
Review

Dietary fiber ameliorates lead-induced gut microbiota disturbance and alleviates neuroinflammation

Mei Yao et al. J Sci Food Agric. 2022 Dec.

Abstract

Dietary fiber (DF) is a carbohydrate from the edible part of plants and has the functions of promoting gastrointestinal motility, regulating gut microbiota (GM) and improving health. Lead is a non-essential toxic heavy metal that can accumulate in the environment over time and enter the body through the respiratory tract, skin and gastrointestinal tract. Lead not only causes disturbances in GM but also leads to loss of homeostasis of immune functions, causes neuronal damage and results in neuroinflammation. The scientific literature has reported that DF had anti-inflammatory activity as a natural product. This review highlights the role of DF and its metabolic products in alleviating lead-induced neuroinflammation by inducing changes in the species and quantity of GM and regulating the immune system, providing a potential dietary protective strategy for lead-induced disease. © 2022 Society of Chemical Industry.

Keywords: alleviate; brain-gut-microbiota axis; dietary fiber; gut microbiota; lead exposure; neuroinflammation.

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