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Editorial
. 2022 Aug 1;40(22):2398-2401.
doi: 10.1200/JCO.22.00733. Epub 2022 Jun 15.

Prenatal DNA Sequencing for Fetal Aneuploidy Also Detects Maternal Cancer: Importance of Timely Workup and Management in Pregnant Women

Amy E Turriff  1 , Christina M Annunziata  2 , Diana W Bianchi  1   3
Affiliations
Editorial

Prenatal DNA Sequencing for Fetal Aneuploidy Also Detects Maternal Cancer: Importance of Timely Workup and Management in Pregnant Women

Amy E Turriff et al. J Clin Oncol. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Christina M. Annunziata

Research Funding: Precision Biologics (Inst), MaxCyte (Inst), Astex Pharmaceuticals (Inst)

Patents, Royalties, Other Intellectual Property: Precision Biologics (Inst), MaxCyte (Inst)

No other potential conflicts of interest were reported.

Figures

FIG 1.
FIG 1.
Current challenges to the identification and management of NIPT results suggestive of maternal malignancy in the United States (US). NIPT, noninvasive prenatal testing.
See this image and copyright information in PMC

Comment on

  • Noninvasive Prenatal Test Results Indicative of Maternal Malignancies: A Nationwide Genetic and Clinical Follow-Up Study.
    Heesterbeek CJ, Aukema SM, Galjaard RH, Boon EMJ, Srebniak MI, Bouman K, Faas BHW, Govaerts LCP, Hoffer MJV, den Hollander NS, Lichtenbelt KD, van Maarle MC, van Prooyen Schuurman L, van Rij MC, Schuring-Blom GH, Stevens SJC, Tan-Sindhunata G, Zamani Esteki M, de Die-Smulders CEM, Tjan-Heijnen VCG, Henneman L, Sistermans EA, Macville MVE; Dutch NIPT Consortium. Heesterbeek CJ, et al. J Clin Oncol. 2022 Aug 1;40(22):2426-2435. doi: 10.1200/JCO.21.02260. Epub 2022 Apr 8. J Clin Oncol. 2022. PMID: 35394817

References

    1. Heesterbeek CJ, Aukema SM, Galjaard RJH, et al. : Noninvasive prenatal test results indicative of maternal malignancies: A nationwide genetic and clinical follow-up study. J Clin Oncol 40:2426-2435, 2022 - PubMed
    1. Gil MM, Accurti V, Santacruz B, et al. : Analysis of cell-free DNA in maternal blood in screening for aneuploidies: Updated meta-analysis. Ultrasound Obstet Gynecol 50:302-314, 2017 - PubMed
    1. Bianchi DW, Chiu RWK: Sequencing of circulating cell-free DNA during pregnancy. N Engl J Med 379:464-473, 2018 - PMC - PubMed
    1. Bianchi DW: Cherchez la femme: Maternal incidental findings can explain discordant prenatal cell-free DNA sequencing results. Genet Med 20:910-917, 2018 - PMC - PubMed
    1. Bianchi DW: Unusual prenatal genomic results provide proof-of-principle of the liquid biopsy for cancer screening. Clin Chem 64:254-256, 2018 - PMC - PubMed