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Comment
. 2022 Jun 14;55(6):967-970.
doi: 10.1016/j.immuni.2022.05.015.

cDC1 to cDC2: "Everything I do, Ido1 it for you"

Mirja Tamara Prentzell  1 , Christiane A Opitz  2
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cDC1 to cDC2: "Everything I do, Ido1 it for you"

Mirja Tamara Prentzell et al. Immunity. .
Free article

Abstract

Distinct dendritic cell (DC) subsets exert specific functions in immune regulation, but their communication with each other has remained elusive. In this issue of Immunity, Gargaro et al. identify the IDO1-Kyn-AHR axis as a metabolic signaling pathway through which conventional DC subsets communicate and induce tolerogenicity.

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Conflict of interest statement

Declaration of interests M.T.P. is listed as inventor on WO2020208190 on IL4I1. C.A.O. is listed as inventor on four patent applications (WO2020201825, WO2020208190, WO2021116357, WO2013034685) on AHR or IL4I1. M.T.P. and C.A.O. receive research funding from Bayer. C.A.O. is founder and chief scientific officer of cAHRmeleon Bioscience GmbH.

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