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Comment
. 2022 Jun 14;55(6):979-981.
doi: 10.1016/j.immuni.2022.05.017.

Big fish in small ponds: Narrow repertoires of stem-like tissue-resident T cells yield great power in anti-tumor immunity

Kellie N Smith  1
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Comment

Big fish in small ponds: Narrow repertoires of stem-like tissue-resident T cells yield great power in anti-tumor immunity

Kellie N Smith. Immunity. .
Free article

Abstract

Metastatic ovarian cancer is a significant clinical challenge due in part to its poor response to immunotherapy. In a recent issue of Cancer Cell, Anandon et al. (2022) identify a population of stem-like tissue-resident memory T cells that are responsible for the bulk of anti-tumor T cell immunity, with insights into improving therapeutic response.

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Conflict of interest statement

Declaration of interests K.N.S. is co-inventor of a patent related to identification of neoantigen-specific T cells (MANAFEST – A Novel Sensitive, Specific, Salable and Simple Method to Identify Functional Anti-Tumor T cell Responses, US provisional patent application no. 62/407,820); owns founders equity in ManaT Bio, Inc.; receives commercial research funding from Bristol-Myers Squibb, AstraZeneca, and Enara Bio; and has received travel support/honorari from Illumina, Inc. and Adaptive Biotechnologies. These arrangements have been reviewed and approved by the Johns Hopkins University in accordance with its conflict of interest policies.

Comment on

  • Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells.
    Anadon CM, Yu X, Hänggi K, Biswas S, Chaurio RA, Martin A, Payne KK, Mandal G, Innamarato P, Harro CM, Mine JA, Sprenger KB, Cortina C, Powers JJ, Costich TL, Perez BA, Gatenbee CD, Prabhakaran S, Marchion D, Heemskerk MHM, Curiel TJ, Anderson AR, Wenham RM, Rodriguez PC, Conejo-Garcia JR. Anadon CM, et al. Cancer Cell. 2022 May 9;40(5):545-557.e13. doi: 10.1016/j.ccell.2022.03.008. Epub 2022 Apr 14. Cancer Cell. 2022. PMID: 35427494 Free PMC article.

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