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Pluripotent stem cells provide a powerful model for the study of human development and its disorders. Recent studies, including two in this issue of Stem Cell Reports, raise important questions concerning the developmental potential of human pluripotent stem cells, and how the behavior of these cells in vitro mirrors normal embryogenesis.
Seetharam AS, Vu HTH, Choi S, Khan T, Sheridan MA, Ezashi T, Roberts RM, Tuteja G.Seetharam AS, et al.Stem Cell Reports. 2022 Jun 14;17(6):1289-1302. doi: 10.1016/j.stemcr.2022.04.014. Epub 2022 May 19.Stem Cell Reports. 2022.PMID: 35594861Free PMC article.
References
Guo G., Stirparo G.G., Strawbridge S.E., Spindlow D., Yang J., Clarke J., Dattani A., Yanagida A., Li M.A., Myers S., et al. Human naive epiblast cells possess unrestricted lineage potential. Cell Stem Cell. 2021;28:1040–1056.e6. doi: 10.1016/j.stem.2021.02.025.
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Io S., Kabata M., Iemura Y., Semi K., Morone N., Minagawa A., Wang B., Okamoto I., Nakamura T., Kojima Y., et al. Capturing human trophoblast development with naive pluripotent stem cells in vitro. Cell Stem Cell. 2021;28:1023–1039.e13. doi: 10.1016/j.stem.2021.03.013.
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Jang Y.J., Kim M., Lee B.K., Kim J. Induction of human trophoblast stem-like cells from primed pluripotent stem cells. Proc. Natl. Acad. Sci. U. S. A. 2022;119 doi: 10.1073/pnas.2115709119.
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Pera M.F., Rossant J. The exploration of pluripotency space: charting cell state transitions in peri-implantation development. Cell Stem Cell. 2021;28:1896–1906. doi: 10.1016/j.stem.2021.10.001.
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Rostovskaya M., Andrews S., Reik W., Rugg-Gunn P.J. Amniogenesis occurs in two independent waves in primates. Cell Stem Cell. 2022;29:744–759.e6. doi: 10.1016/j.stem.2022.03.014.
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