Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Jun 13;9(2):82-89.
doi: 10.1055/s-0042-1743259. eCollection 2022 Jun.

Psoriasis: An Immunogenetic Perspective

Ayca Kocaaga  1 , Mustafa Kocaaga  2
Affiliations
Review

Psoriasis: An Immunogenetic Perspective

Ayca Kocaaga et al. Glob Med Genet. .

Abstract

Psoriasis is an erythematous-squamous dermatosis with a polygenic inheritance history. Both environmental and genetic factors play a role in the etiology of the disease. Over the past two decades, numerous linkage analyzes and genome-wide association studies have been conducted to investigate the role of genetic variation in disease pathogenesis and progression. To date, >70 psoriasis susceptibility loci have been identified, including HLA-Cw6, IL12B, IL23R, and LCE3B/3C. Some genetic markers are used in clinical diagnosis, prognosis, treatment, and personalized new drug development that can further explain the pathogenesis of psoriasis. This review summarizes the immunological mechanisms involved in the etiopathogenesis of psoriasis and recent advances in susceptibility genes and highlights new potential targets for therapeutic intervention.

Keywords: autoimmune; genome-wide association study; immunogenetics; psoriasis.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest None declared.

Figures

Fig. 1
Fig. 1
Summary of cytokine involvement in the pathogenesis of psoriasis.
See this image and copyright information in PMC

References

    1. Gisondi P, Bellinato F, Girolomoni G, Albanesi C. Pathogenesis of chronic plaque psoriasis and its intersection with cardio-metabolic comorbidities. Front Pharmacol. 2020;11:117. - PMC - PubMed
    1. Liu T, Li S, Ying S. The IL-23/IL-17 pathway in inflammatory skin diseases: from bench to bedside. Front Immunol. 2020;11:594735. - PMC - PubMed
    1. Global Psoriasis Atlas . Parisi R, Iskandar I YK, Kontopantelis E, Augustin M, Griffiths C EM, Ashcroft D M. National, regional, and worldwide epidemiology of psoriasis: systematic analysis and modelling study. BMJ. 2020;369:m1590. - PMC - PubMed
    1. Xu X, Zhang H Y. The immunogenetics of psoriasis and implications for drug repositioning. Int J Mol Sci. 2017;18(12):E2650. - PMC - PubMed
    1. Harden J L, Krueger J G, Bowcock A M. The immunogenetics of psoriasis: a comprehensive review. J Autoimmun. 2015;64:66–73. - PMC - PubMed