Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jun 8:15:775-781.
doi: 10.2147/JAA.S354082. eCollection 2022.

Clinical Features and Outcomes Associated with Bronchial Asthma Among COVID-19 Hospitalized Patients

Miguel Angel Diaz  1 , Nelly Catalan-Caceres  1 , Thais C Beauperthuy  2 , Carlos Domingo  1 , Ethel Ibañez  1 , Carmen Morata  3 , Alfredo De Diego  2
Affiliations

Clinical Features and Outcomes Associated with Bronchial Asthma Among COVID-19 Hospitalized Patients

Miguel Angel Diaz et al. J Asthma Allergy. .

Abstract

Background: The impact of diagnosis treatment and bronchial asthma on coronavirus disease 2019 (COVID-19) associated outcomes remains unclear.

Objective: To identify the prevalence and outcomes associated with asthma among hospitalized patients with COVID-19.

Methods: Electronic health records of 130 patients with asthma among hospitalized patients with COVID-19 were reviewed. Two subgroups of asthmatic patients were compared according to clinical outcomes during hospitalization. Patients with death results, intubation, and/or need of intensive care unit (ICU) stay were grouped as asthmatic patients with severe COVID-19 outcomes, and the rest were grouped as asthmatic patients with non-severe COVID-19 outcomes. Multivariable analyses were conducted with logistic regression to identify independent risk factors for severe outcomes.

Results: The prevalence of asthma in COVID-19 hospitalized patients was 5%. The mean age was 59.4 years and 54% were women. 17% received treatment in GINA step 4-5 asthma at the time of admission. An allergic asthma phenotype was determined in 38%. There was no significant difference in hospital length of stay or need for intubation between asthmatic patients and global COVID-19 admitted patients. 17% of asthmatic patients developed a severe outcome, and 5% had a death result. Elevated Lactate Dehydrogenase (LDH) level, low transcutaneous pulse oximetry (SpO2), the coexistence of atrial fibrillation (AF), and need for moderate or high ICS at admission were independent risk factors for a worse outcome in asthmatics COVID-19 hospitalized patients.

Conclusion: The prevalence of asthma in COVID-19 hospitalized patients was 5%, consistent with the asthma prevalence in the general population. The asthmatic patients with the previous prescription of moderate or high doses of ICS and/or coexistence of atrial fibrillation at admission had a higher risk of the severe outcome.

Keywords: COVID-19; bronchial asthma; outcomes; risk factors.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interest in this work.

References

    1. Zhang J, Dong X, Cao Y, et al. Clinical characteristics of 140 patients infected with SARS‐CoV‐2 in Wuhan, China. Allergy. 2020;75(7):1730–1741. doi:10.1111/all.14238 - DOI - PubMed
    1. Li X, Xu S, Yu M, et al. Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan. J Allergy Clin Immunol. 2020;146(1):110–118. doi:10.1016/j.jaci.2020.04.006 - DOI - PMC - PubMed
    1. Wang Y, Ao G, Qi X, Xie B. The association between COVID‐19 and asthma: a systematic review and meta‐analysis. Clin Exp Allergy. 2020;50(11):1274–1277. doi:10.1111/cea.13733 - DOI - PubMed
    1. Mendes NF, Jara CP, Mansour E, Araújo EP, Velloso LA. Asthma and COVID-19: a systematic review. Allergy, Asthma Clin Immunol. 2021;17(1). doi:10.1186/s13223-020-00509-y - DOI - PMC - PubMed
    1. Eggert LE, He Z, Collins W, et al. Asthma phenotypes, associated comorbidities, and long‐term symptoms in COVID‐19. Allergy. 2021;19(1):173–185. - PMC - PubMed