Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022;10(3):194-209.
doi: 10.2174/2211738510666220615154841.

The Potential of Microbubbles as a Cancer Eradication Theranostic Agent

Atul Chaudhary  1 , Aseem Setia  2 , Dilpreet Singh  1 , Sankha Bhattacharya  3
Affiliations
Review

The Potential of Microbubbles as a Cancer Eradication Theranostic Agent

Atul Chaudhary et al. Pharm Nanotechnol. 2022.

Abstract

Microbubbles are a new kind of delivery system that may be used to treat a variety of illnesses, including cancer. Microbubble is a non-invasive technology that uses microscopic gasfilled colloidal particle bubbles with a size range of less than 100 micrometres. This unique carrier has been used in a variety of applications in the last decade, ranging from basic targeting to ultrasound- mediated drug delivery. The oxygen in the microbubble lasts longer in the water. The drug release mechanism is highly regulated, since it releases the medication only in the appropriate areas, increasing the local impact while reducing drug toxicity. This carrier is exceptional in cancer medication delivery because of its sustained stability, encapsulation efficiency, and drug targeting. In this paper, we provide a comprehensive analysis of microbubble technology, including its manufacturing techniques and use in cancer medication delivery.

Keywords: Cancer; coaxial electrohydrodynamic atomisation; drug targeting; magnetic resonance imaging; microbubbles; novel delivery.

PubMed Disclaimer

References

    1. Wang Z.; Huang H.; Chen Y.; Zheng Y.; Current strategies for microbubble-based thrombus targeting: Activation-specific epitopes and small molecular ligands. Front Bioeng Biotechnol 2021,9,699450 - DOI - PubMed
    1. Frigenti G.; Cavigli L.; Ratto F.; Microbubble resonators for scattering-free absorption spectroscopy of nanoparticles. Opt Express 2021,29(20),31130-31136 - DOI - PubMed
    1. Lee Y.N.; Wu Y.J.; Lee H.I.; Ultrasonic microbubble VEGF gene delivery improves angiogenesis of senescent endothelial progenitor cells. Sci Rep 2021,11(1),13449 - DOI - PubMed
    1. Omata D.; Munakata L.; Maruyama K.; Suzuki R.; Ultrasound and microbubble-mediated drug delivery and immunotherapy. J Med Ultrason 2022 - DOI
    1. Peng C.; Wu Y.; Yang Y.; Using ultrasound-targeted microbubble destruction to enhance radiotherapy of glioblastoma. J Cancer Res Clin Oncol 2021,147(5),1355-1363 - DOI - PubMed

MeSH terms

Substances

LinkOut - more resources