Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jun 16;17(6):e0270019.
doi: 10.1371/journal.pone.0270019. eCollection 2022.

The correlation between serum albumin and diabetic retinopathy among people with type 2 diabetes mellitus: NHANES 2011-2020

Gao-Xiang Wang  1   2 , Ze-Bin Fang  2   3 , Jun-Tong Li  1   2 , Bao-Li Huang  2   3 , De-Liang Liu  2 , Shu-Fang Chu  2 , Hui-Lin Li  2
Affiliations

The correlation between serum albumin and diabetic retinopathy among people with type 2 diabetes mellitus: NHANES 2011-2020

Gao-Xiang Wang et al. PLoS One. .

Abstract

Objectives: The objective of this research aimed to investigate the correlation involving serum albumin with diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM).

Methods: From 2011 to 2020, the National Health and Nutrition Examination Survey (NHANES) surveyed 45462 participants. We used the relevant data to conduct descriptive statistics, linear regression, and Logistic regression analysis.

Results: After adjusting for age, sex, and race, as well as all other variables, serum albumin was significantly negatively related to DR (P<0.001). Furthermore, after controlling for confounding factors, the third quartile (Q3) and the fourth quartile (Q4) had quite a negative significant relationship with the incidence of DR (P<0.01). The second quartile had a significant positive correlation with DR, whereas the observed negative correlations were not statistically meaningful (P>0.05).

Conclusion: Albumin levels in the serum have a quantitatively significant negative correlation with DR. Serum albumin levels in the blood can be used as a reference point for protracted follow-up of people with T2DM.

PubMed Disclaimer

Conflict of interest statement

NO authors have competing interests.

Figures

Fig 1
Fig 1. Flowchart of study target population NHANES (2011–2020).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, et al.. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Research and Clinical Practice. 2019;157: 107843. doi: 10.1016/j.diabres.2019.107843 - DOI - PubMed
    1. Teo ZL, Tham Y-C, Yu M, Chee ML, Rim TH, Cheung N, et al.. Global Prevalence of Diabetic Retinopathy and Projection of Burden through 2045. Ophthalmology. 2021;128: 1580–1591. doi: 10.1016/j.ophtha.2021.04.027 - DOI - PubMed
    1. Steinmetz JD, Bourne RRA, Briant PS, Flaxman SR, Taylor HRB, Jonas JB, et al.. Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study. The Lancet Global Health. 2021;9: e144–e160. doi: 10.1016/S2214-109X(20)30489-7 - DOI - PMC - PubMed
    1. Hammoudi J, Bouanani NEH, Chelqi EH, Bentata Y, Nouayti H, Legssyer A, et al.. Diabetic retinopathy in the Eastern Morocco: Different stage frequencies and associated risk factors. Saudi Journal of Biological Sciences. 2021;28: 775–784. doi: 10.1016/j.sjbs.2020.11.010 - DOI - PMC - PubMed
    1. Wang W, Lo A. Diabetic Retinopathy: Pathophysiology and Treatments. IJMS. 2018;19: 1816. doi: 10.3390/ijms19061816 - DOI - PMC - PubMed

Publication types