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. 2022 Jun 16;17(6):e0270019.
doi: 10.1371/journal.pone.0270019. eCollection 2022.

The correlation between serum albumin and diabetic retinopathy among people with type 2 diabetes mellitus: NHANES 2011-2020

Gao-Xiang Wang  1   2 , Ze-Bin Fang  2   3 , Jun-Tong Li  1   2 , Bao-Li Huang  2   3 , De-Liang Liu  2 , Shu-Fang Chu  2 , Hui-Lin Li  2
Affiliations

The correlation between serum albumin and diabetic retinopathy among people with type 2 diabetes mellitus: NHANES 2011-2020

Gao-Xiang Wang et al. PLoS One. .

Abstract

Objectives: The objective of this research aimed to investigate the correlation involving serum albumin with diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM).

Methods: From 2011 to 2020, the National Health and Nutrition Examination Survey (NHANES) surveyed 45462 participants. We used the relevant data to conduct descriptive statistics, linear regression, and Logistic regression analysis.

Results: After adjusting for age, sex, and race, as well as all other variables, serum albumin was significantly negatively related to DR (P<0.001). Furthermore, after controlling for confounding factors, the third quartile (Q3) and the fourth quartile (Q4) had quite a negative significant relationship with the incidence of DR (P<0.01). The second quartile had a significant positive correlation with DR, whereas the observed negative correlations were not statistically meaningful (P>0.05).

Conclusion: Albumin levels in the serum have a quantitatively significant negative correlation with DR. Serum albumin levels in the blood can be used as a reference point for protracted follow-up of people with T2DM.

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Conflict of interest statement

NO authors have competing interests.

Figures

Fig 1
Fig 1. Flowchart of study target population NHANES (2011–2020).
See this image and copyright information in PMC

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