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Comment
. 2022 Jun 17;376(6599):1270-1271.
doi: 10.1126/science.abq7217. Epub 2022 Jun 16.

Modifying insulin to improve performance

Nai-Pin Lin  1 , Danny Hung-Chieh Chou  1
Affiliations
Comment

Modifying insulin to improve performance

Nai-Pin Lin et al. Science. .

Abstract

A platform to enable precise modifications of insulin could improve drug functionality.

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  • A chemoenzymatic strategy for site-selective functionalization of native peptides and proteins.
    Fryszkowska A, An C, Alvizo O, Banerjee G, Canada KA, Cao Y, DeMong D, Devine PN, Duan D, Elgart DM, Farasat I, Gauthier DR, Guidry EN, Jia X, Kong J, Kruse N, Lexa KW, Makarov AA, Mann BF, Milczek EM, Mitchell V, Nazor J, Neri C, Orr RK, Orth P, Phillips EM, Riggins JN, Schafer WA, Silverman SM, Strulson CA, Subramanian N, Voladri R, Yang H, Yang J, Yi X, Zhang X, Zhong W. Fryszkowska A, et al. Science. 2022 Jun 17;376(6599):1321-1327. doi: 10.1126/science.abn2009. Epub 2022 Jun 16. Science. 2022. PMID: 35709255

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