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Comment
. 2022 Jun 15;110(12):1891-1893.
doi: 10.1016/j.neuron.2022.05.014.

General anesthesia and the cortical stranglehold on consciousness

Dinesh Pal  1 , George A Mashour  2
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General anesthesia and the cortical stranglehold on consciousness

Dinesh Pal et al. Neuron. .
Free article

Abstract

In this issue of Neuron, Bharioke et al. (2022) demonstrate that diverse general anesthetic regimens all reversibly and selectively synchronize spontaneous activity of pyramidal neurons in layer 5 of mouse cortex. We discuss the implications of these findings for the mechanism of consciousness and anesthetic-induced unconsciousness.

Keywords: consciousness; cortex; general anesthesia; layer 5; neuronal synchrony.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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