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. 1987 Mar;40(3):370-84.
doi: 10.7164/antibiotics.40.370.

Studies on orally active cephalosporin esters

K Fujimoto, S Ishihara, H Yanagisawa, J Ide, E Nakayama, H Nakao, S Sugawara, M Iwata
Free article

Studies on orally active cephalosporin esters

K Fujimoto et al. J Antibiot (Tokyo). 1987 Mar.
Free article

Abstract

The synthesis and the biological properties of orally active cephalosporin esters are described. 3-Methoxymethyl cephem derivatives having a 2-(2-aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamide function at C-7 (1) showed good activity against a wide variety of bacteria including some beta-lactamase producing species. The prodrug type esters of 1 exhibited a good urinary recovery after oral administration to mice and 1-(isopropoxycarbonyloxy)ethyl ester (2a, CS-807) has been pre-clinically tested as an orally active cephem prodrug.

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