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. 2022 Jun 14;12(3):25-36.
doi: 10.1093/af/vfac026. eCollection 2022 Jun.

Osteoarthritis: a common disease that should be avoided in the athletic horse's life

Raquel Yvonne Arantes Baccarin  1 , Sarah Raphaela Torquato Seidel  1 , Yara Maria Michelacci  2 , Paula Keiko Anadão Tokawa  1 , Tiago Marcelo Oliveira  1
Affiliations

Osteoarthritis: a common disease that should be avoided in the athletic horse's life

Raquel Yvonne Arantes Baccarin et al. Anim Front. .
No abstract available

Keywords: athletic horses; osteoarthritis; performance; welfare.

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Figures

Figure 1.
Figure 1.
Articular cartilage ECM: components (A) and organization (B). There are differences in the ECM composition at the pericellular and “territorial zone”, closer to the cells, in comparison to the “interterritorial zone”. The interterritorial zone is composed of a fibrillar collagen network, consisting primarily of type II collagen fibrils with types XI and IX collagens integrated. In contrast, the territorial matrix contains type VI collagen microfibrils, but little fibrillar collagen.
Figure 2.
Figure 2.
Changes in cartilage organization in OA. The depletion of aggrecan, as the result of proteolytic cleavage of the aggrecan core protein by proteases, is a key event in OA. IL-1β creates an inflammation microenvironment that leads to the loss of ECM components, chondrocyte hypertrophy, and terminal differentiation. Chondrocytes begin to express Runt-related transcription factor (RUNX2), vascular endothelial growth factor (VEGF), collagen X, and MMP13. Calcification of the ECM around chondrocytes follows this shift towards hypertrophy, leading to subchondral bone sclerosis.
Figure 3.
Figure 3.
Manual physio therapy on thoracic limbs. Passive stretching (A, B, C) with possibility of joint mobilization (B, C); and active stretching of neck (D, E).
See this image and copyright information in PMC

References

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