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Comment
. 2022 Jun 24;7(72):eabp8632.
doi: 10.1126/sciimmunol.abp8632. Epub 2022 Jun 17.

Regional specification of oral mucosal immunity

Drake W Williams  1 , George Hajishengallis  2 , Niki M Moutsopoulos  1
Affiliations
Comment

Regional specification of oral mucosal immunity

Drake W Williams et al. Sci Immunol. .

Abstract

In this issue of Science Immunology, Barreto de Albuquerque et al. track immune responsiveness to the foodborne pathogen Listeria monocytogenes during oral infection. Their findings extend the notion of compartmentalized immunity within the gastrointestinal tract to the oral cavity and provide previously unkown insights into regional specialization of oral immunity.

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Figures

Fig. 1.
Fig. 1.. Intraoral infection with Lm through contaminated food.
(A) Lm reaches the submandibular LNs partially through the regional lymphatic network. Within the first 1 to 2 days after i.o. infection, CD8+, antigen- specific TEFF cells expand in the regional lymphatics (mandLNs) and disseminate into the circulation. (B) Oral-LN–primed TEFF cells display specific patterns of dissemination and traffic to the spleen, oral mucosa, and lung, providing protection to distal organs such as the spleen. However, mandLN TEFF cells do not display a gut-homing phenotype, suggesting regional specialization of TEFF cells induced by i.o. infection with Lm.
See this image and copyright information in PMC

Comment on

References

    1. Gaffen SL, Moutsopoulos NM, Regulation of host-microbe interactions at oral mucosal barriers by type 17 immunity. Sci. Immunol 5, eaau4594 (2020). - PMC - PubMed
    1. Barreto de Albuquerque J, Altenburger LM, Abe J, von Werdt D, Wissmann S, Magdaleno JM, Francisco D, van Geest G, Ficht X, Iannacone M, Bruggmann R, Mueller C, Stein JV, Microbial uptake in oral mucosa-draining lymph nodes leads to rapid release of cytotoxic CD8+ T cells lacking a gut-homing phenotype. Sci. Immunol 7, abf1861 (2022). - PubMed
    1. Paris AL, Colomb E, Verrier B, Anjuere F, Monge C, Sublingual vaccination and delivery systems. J. Control. Release 332, 553–562 (2021). - PubMed
    1. Silva-Dos-Santos D, Barreto-de-Albuquerque J, Guerra B, Moreira OC, Berbert LR, Ramos MT, Mascarenhas BAS, Britto C, Morrot A, Serra Villa-Verde DM, Garzoni LR, Savino W,Cotta-de-Almeida V, de Meis J, Unraveling Chagas disease transmission through the oral route: Gateways to Trypanosoma cruzi infection and target tissues. PLOS Negl. Trop. Dis 11, e0005507 (2017). - PMC - PubMed
    1. Michalek SM, McGhee JR, Mestecky J, Arnold RR, Bozzo L, Ingestion of Streptococcus mutans induces secretory immunoglobulin A and caries immunity. Science 192, 1238–1240 (1976). - PubMed

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