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Comment
. 2022 Jun 16;82(12):2188-2189.
doi: 10.1016/j.molcel.2022.05.033.

TADs do not stay in the loop

Davide Michieletto  1 , Wendy A Bickmore  2
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TADs do not stay in the loop

Davide Michieletto et al. Mol Cell. .
Free article

Erratum in

  • TADs do not stay in the loop.
    Michieletto D, Bickmore WA. Michieletto D, et al. Mol Cell. 2022 Sep 1;82(17):3312. doi: 10.1016/j.molcel.2022.08.013. Mol Cell. 2022. PMID: 36055207 No abstract available.

Abstract

In a recent issue of Science, Gabriele et al. have, for the first time, quantified the dynamics of a topologically associating domain (TAD) in live cells by coupling super-resolution imaging and computational modelling, concluding that a TAD spends most of its life in a "partially extruded state" and that CTCF-CTCF loops are rare.

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Declaration of interests The authors declare no competing interests.

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